Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA.
University of California Davis, Davis, CA, 95616, USA.
Adv Mater. 2018 Dec;30(51):e1803355. doi: 10.1002/adma.201803355. Epub 2018 Oct 17.
Biological membranes provide a fascinating example of a separation system that is multifunctional, tunable, precise, and efficient. Biomimetic membranes, which mimic the architecture of cellular membranes, have the potential to deliver significant improvements in specificity and permeability. Here, a fully synthetic biomimetic membrane is reported that incorporates ultra-efficient 1.5 nm diameter carbon nanotube porin (CNTPs) channels in a block-copolymer matrix. It is demonstrated that CNTPs maintain high proton and water permeability in these membranes. CNTPs can also mimic the behavior of biological gap junctions by forming bridges between vesicular compartments that allow transport of small molecules.
生物膜提供了一个令人着迷的分离系统范例，它具有多功能、可调谐、精确和高效的特点。仿生膜模仿细胞膜的结构，有可能在特异性和通透性方面带来显著的改善。在这里，报告了一种完全合成的仿生膜，它在嵌段共聚物基质中包含超高效的 1.5nm 直径碳纳米管孔蛋白（CNTP）通道。研究表明，CNTP 在这些膜中保持高质子和水通透性。CNTP 还可以通过在允许小分子运输的囊泡隔室之间形成桥来模拟生物间隙连接的行为。
