Creatv MicroTech, Inc., Rockville, Maryland.
Creatv MicroTech, Inc., Chicago, Illinois.
Cytometry A. 2018 Dec;93(12):1246-1250. doi: 10.1002/cyto.a.23573. Epub 2018 Oct 19.
Circulating tumor cells (CTCs), epithelial-mesenchymal transition (EMT) cells, as well as a number of circulating cancer stromal cells (CStCs) are known to shed into the blood of cancer patients. Individually, and together, these cells provide biological and clinical information about the cancers. Filtration is a method used to isolate all of these cells, while eliminating red and white blood cells from whole peripheral blood. We have previously shown that accurate identification of these cell types is paramount to proper clinical assessment by describing the overlapping phenotypes of CTCs to one such CStC, the cancer-associated macrophage-like cell (CAML). We report that CAMLs possess a number of parallel applications to CTCs but have a broader range of clinical utility, including cancer screening, companion diagnostics, diagnosis, prognosis, monitoring of treatment response, and detection of recurrence. © 2018 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of ISAC.
循环肿瘤细胞（CTCs）、上皮-间充质转化（EMT）细胞以及许多循环肿瘤基质细胞（CStCs）已知会脱落到癌症患者的血液中。这些细胞单独或共同提供有关癌症的生物学和临床信息。过滤是一种用于分离所有这些细胞的方法，同时从全血中消除红细胞和白细胞。我们之前通过描述 CTCs 与一种 CStC（癌症相关巨噬细胞样细胞（CAML））重叠的表型，表明准确识别这些细胞类型对于正确的临床评估至关重要。我们报告说，CAMLs 具有许多与 CTCs 平行的应用，但具有更广泛的临床应用，包括癌症筛查、伴随诊断、诊断、预后、治疗反应监测和复发检测。 2018 年作者。流式细胞术部分由 Wiley Periodicals，Inc. 代表 ISAC 出版。
