Stora C, Dvorackova I
J Med. 1987;18(1):23-41.
Thirty-eight cases of primary liver cancer (PLC) from the Department of Pathology, Charles University, Hradec Kralové were investigated. The viral hepatitis HBsAg antigen was found in the sera of 8 of the 38 patients. Radioimmunoassay demonstrated aflatoxin in 27 of 34 cases. Fluorescence microscopy revealed a fluorescence characteristic of aflatoxin and its fluorescent metabolites in the peritumoral tissue and the tumor for all of the cases studied. This study emphasizes the increasing incidence of PLC over the last 15 years. In addition, this type of cancer now appears to develop in a different manner: reduction in the number of cases with cirrhosis, progressive rise in the number of women affected, and occurrence of PLC in children and adolescents. These observations tend to indicate that aflatoxin might play a significant role in the genesis of PLC.
对布拉格克拉洛韦查理大学病理科的38例原发性肝癌（PLC）病例进行了调查。在38例患者中的8例血清中发现了病毒性肝炎HBsAg抗原。放射免疫分析显示34例中有27例存在黄曲霉毒素。荧光显微镜检查显示，在所研究的所有病例中，肿瘤周围组织和肿瘤中均有黄曲霉毒素及其荧光代谢产物的荧光特征。本研究强调了过去15年中PLC发病率的上升。此外，现在这种类型的癌症似乎以不同的方式发展：肝硬化病例数量减少，受影响女性数量逐渐增加，以及儿童和青少年中出现PLC。这些观察结果倾向于表明黄曲霉毒素可能在PLC的发生中起重要作用。
