鼠冠状病毒JHM诱导星形胶质细胞Ia抗原的能力取决于大鼠品系。
Inducibility of Ia antigen on astrocytes by murine coronavirus JHM is rat strain dependent.
作者信息
Massa P T, Brinkmann R, ter Meulen V
出版信息
J Exp Med. 1987 Jul 1;166(1):259-64. doi: 10.1084/jem.166.1.259.
Abstract
Inducibility of Ia molecules on cultivated astrocytes by JHM virus correlates with demyelinating disease susceptibility of animals from which these astrocytes are derived. On the contrary, class I induction of both astrocytes and oligodendrocytes occurs as a consequence of normal cultivation procedures in both susceptible and resistant strains. Increased expression of class I antigens on rat astrocytes and oligodendrocytes is not related to JHM viral infection as it is in the mouse. These data indicate that strain differences in Ia inducibility, rather than inducibility of class I antigens, by JHM virus may explain higher levels of T cell-mediated damage to myelin during infection in susceptible rat strains compared with resistant strains.
摘要
JHM病毒对培养的星形胶质细胞Ia分子的诱导能力与这些星形胶质细胞来源动物的脱髓鞘疾病易感性相关。相反，在易感和抗性品系中，星形胶质细胞和少突胶质细胞的I类诱导是正常培养程序的结果。大鼠星形胶质细胞和少突胶质细胞上I类抗原表达的增加与JHM病毒感染无关，而在小鼠中则相关。这些数据表明，JHM病毒诱导Ia的能力差异而非诱导I类抗原的能力差异，可能解释了与抗性品系相比，易感大鼠品系在感染期间T细胞介导的髓鞘损伤水平更高的原因。
相似文献
1
Inducibility of Ia antigen on astrocytes by murine coronavirus JHM is rat strain dependent.鼠冠状病毒JHM诱导星形胶质细胞Ia抗原的能力取决于大鼠品系。
J Exp Med. 1987 Jul 1;166(1):259-64. doi: 10.1084/jem.166.1.259.
2
Analysis and pathogenetic significance of class II MHC (Ia) antigen induction on astrocytes during JHM coronavirus infection in rats.大鼠感染JHM冠状病毒期间星形胶质细胞上II类MHC（Ia）抗原诱导的分析及其致病意义
Adv Exp Med Biol. 1987;218:203-17. doi: 10.1007/978-1-4684-1280-2_25.
3
4
Coronavirus JHM infection of rats as a model for virus induced demyelinating encephalomyelitis.冠状病毒JHM感染大鼠作为病毒诱导的脱髓鞘性脑脊髓炎模型。
Prog Clin Biol Res. 1984;146:13-22.
5
6
Analysis of Ia induction on Lewis rat astrocytes in vitro by virus particles and bacterial adjuvants.病毒颗粒和细菌佐剂对体外培养的Lewis大鼠星形胶质细胞Ia诱导作用的分析。
J Neuroimmunol. 1987 Jan;13(3):259-71. doi: 10.1016/0165-5728(87)90062-2.
7
Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.星形胶质细胞上Ia抗原的超诱导性与实验性自身免疫性脑脊髓炎的品系特异性易感性相关。
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4219-23. doi: 10.1073/pnas.84.12.4219.
8
Tumor necrosis factor amplifies measles virus-mediated Ia induction on astrocytes.肿瘤坏死因子增强麻疹病毒介导的星形胶质细胞Ia诱导作用。
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7242-5. doi: 10.1073/pnas.84.20.7242.
9
Coronavirus induced primary demyelination: indications for the involvement of a humoral immune response.冠状病毒诱导的原发性脱髓鞘：体液免疫反应参与的迹象。
Neuropathol Appl Neurobiol. 1991 Dec;17(6):469-84. doi: 10.1111/j.1365-2990.1991.tb00750.x.
引用本文的文献
1
Transcriptional regulation of MHC class I gene expression in rat oligodendrocytes.大鼠少突胶质细胞中MHC I类基因表达的转录调控
Biochem J. 1998 Feb 15;330 ( Pt 1)(Pt 1):155-61. doi: 10.1042/bj3300155.
2
Borna disease virus and the brain.博尔纳病病毒与大脑
Brain Res Bull. 1997;44(6):647-64. doi: 10.1016/s0361-9230(97)00276-1.
3
Murine coronavirus infection: a paradigm for virus-induced demyelinating disease.小鼠冠状病毒感染：病毒诱导的脱髓鞘疾病的范例
Trends Microbiol. 1997 Jan;5(1):9-14. doi: 10.1016/S0966-842X(97)81768-4.
4
Immunopathological aspects of coronavirus infections.冠状病毒感染的免疫病理学方面
Springer Semin Immunopathol. 1995;17(2-3):133-48. doi: 10.1007/BF00196162.
5
Pathogenesis of virus-induced demyelination.病毒诱导的脱髓鞘病变的发病机制。
Adv Virus Res. 1993;42:249-324. doi: 10.1016/s0065-3527(08)60087-1.
6
Specific suppression of major histocompatibility complex class I and class II genes in astrocytes by brain-enriched gangliosides.脑富集神经节苷脂对星形胶质细胞中主要组织相容性复合体I类和II类基因的特异性抑制作用。
J Exp Med. 1993 Oct 1;178(4):1357-63. doi: 10.1084/jem.178.4.1357.
7
Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo.T细胞介导的小鼠肝炎病毒在体内从神经元中清除过程中的细胞因子诱导
J Virol. 1994 Sep;68(9):5483-95. doi: 10.1128/JVI.68.9.5483-5495.1994.
8
Cell-mediated immunity in virus infections of the central nervous system.中枢神经系统病毒感染中的细胞介导免疫。
Ann N Y Acad Sci. 1988;540(1):228-39. doi: 10.1111/j.1749-6632.1988.tb27065.x.
9
10
Sites of antigen presentation in T-cell mediated demyelinating diseases.T细胞介导的脱髓鞘疾病中的抗原呈递部位。
Res Immunol. 1989 Feb;140(2):196-201; discussion 245-8. doi: 10.1016/0923-2494(89)90086-2.
本文引用的文献
1
Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.用抗半乳糖脑苷脂单克隆抗体研究少突胶质细胞和施万细胞的发育。
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2709-13. doi: 10.1073/pnas.79.8.2709.
2
Rat neural antigen-2 (RAN-2): a cell surface antigen on astrocytes, ependymal cells, Müller cells and lepto-meninges defined by a monoclonal antibody.大鼠神经抗原2（RAN-2）：一种由单克隆抗体定义的星形胶质细胞、室管膜细胞、穆勒细胞和软脑膜上的细胞表面抗原。
Brain Res. 1981 Jan 12;204(2):339-51. doi: 10.1016/0006-8993(81)90593-x.
3
Distribution and quantitation of HLA-ABC and DR (Ia) antigens on human kidney and other tissues.人类肾脏及其他组织上HLA - ABC和DR（Ia）抗原的分布与定量
Transplantation. 1980 Apr;29(4):274-79. doi: 10.1097/00007890-198004000-00002.
4
Long-term culture of human oligodendrocytes. Isolation, growth and identification.人少突胶质细胞的长期培养。分离、生长与鉴定。
J Neurol Sci. 1983 Dec;62(1-3):295-301. doi: 10.1016/0022-510x(83)90206-x.
5
Expression of Ia antigens by cultured astrocytes treated with gamma-interferon.经γ干扰素处理的培养星形胶质细胞Ia抗原的表达
Neurosci Lett. 1983 Oct 31;41(1-2):199-204. doi: 10.1016/0304-3940(83)90247-1.
6
Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis.从患有冠状病毒诱导的脱髓鞘性脑脊髓炎的大鼠身上进行实验性自身免疫性脑脊髓炎样病变的过继转移。
Nature. 1983;305(5930):150-3. doi: 10.1038/305150a0.
7
Astrocytes present myelin basic protein to encephalitogenic T-cell lines.星形胶质细胞将髓鞘碱性蛋白呈递给致脑炎T细胞系。
Nature. 1984;307(5948):273-6. doi: 10.1038/307273a0.
8
Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus.抗大鼠主要组织相容性抗原的小鼠单克隆抗体。两种Ia抗原以及Ia和I类抗原在大鼠胸腺中的表达。
Eur J Immunol. 1982 Mar;12(3):237-43. doi: 10.1002/eji.1830120313.
9
Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection.冠状病毒JHM感染过程中大鼠复发性亚急性脱髓鞘性脑脊髓炎
J Neuroimmunol. 1984 Aug;6(5):325-36. doi: 10.1016/0165-5728(84)90022-5.
10
Interferon-gamma induces the expression of H-2 and Ia antigens on brain cells.γ干扰素可诱导脑细胞上H-2和Ia抗原的表达。
J Neuroimmunol. 1985 Feb-Mar;7(5-6):255-78. doi: 10.1016/s0165-5728(84)80026-0.
Zotero 插件