Mountford P J, Heap R B, Hamon M, Fleet I R, Coakley A J
J Nucl Med. 1987 Jul;28(7):1187-91.
Lactating goats were infused with either technetium-99m (99mTc) or iodine-123 (123I) together with chlorine-36 (36Cl) through an indwelling catheter previously placed in an external pudic mammary artery. The radioisotope infusions were repeated together with 100 mg of sodium perchlorate. There was a rapid transfer of 99mTc and 123I into milk, reaching a peak concentration 30 min after a 15-min infusion. The fractional secretion of 99mTc and 123I in milk was reduced by 70%-80% and 60%-66%, respectively, by perchlorate. The fractional secretion of 36Cl was not affected by perchlorate, and the shape of the 36Cl secretion curve differed from those of 99mTc and 123I, which were similar. It is probable, therefore, that the latter nuclides were secreted by a transport route different from that of chloride. Available data describing the secretion of 99mTc in human milk after pertechnetate administration was reviewed, and it was concluded that perchlorate pretreatment significantly reduced the secretion of 99mTc in human breast milk.
通过预先置于阴部外乳动脉的留置导管，向泌乳山羊输注锝 - 99m（99mTc）或碘 - 123（123I）以及氯 - 36（36Cl）。放射性同位素输注与100mg高氯酸钠一起重复进行。99mTc和123I迅速转移到乳汁中，在15分钟输注后30分钟达到峰值浓度。高氯酸盐使99mTc和123I在乳汁中的分数分泌分别降低了70% - 80%和60% - 66%。36Cl的分数分泌不受高氯酸盐影响，且36Cl分泌曲线的形状与99mTc和123I的不同，后两者相似。因此，很可能后两种核素通过与氯不同的转运途径分泌。回顾了描述高锝酸盐给药后99mTc在人乳中分泌的现有数据，得出结论：高氯酸盐预处理显著降低了99mTc在人母乳中的分泌。
