Student Research Committee, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2019 May;234(5):5537-5554. doi: 10.1002/jcp.27362. Epub 2018 Oct 28.
Poor wound healing is a highly prevalent clinical problem with, as yet, no entirely satisfactory solution. A new technique, termed electrospinning, may provide a solution to improve wound healing. Due to their large surface area to volume ratio and porosity, the nanofibers created by electrospinning are able to deliver sustained drug release and oxygen to the wound. Using different types of polymers with varying properties helps strengthening nanofiber and exudates absorption. The nanofibers appear to have an ideal structure applicable for wound healing and, in combination with curcumin, can blend the anti-inflammatory and antioxidant properties of curcumin into a highly effective wound dressing. The use of suitable curcumin solvents and the slow release of curcumin from the nanofiber help in overcoming the known limitations of curcumin, specifically its low stability and limited bioavailability. Here, we review the studies which have been done on synthesized nanofibers containing curcumin, produced by the electrospinning technique, for the purpose of wound healing.
伤口愈合不良是一种普遍存在的临床问题，目前尚无完全令人满意的解决方案。一种新的技术，称为电纺丝，可能为改善伤口愈合提供解决方案。由于其大的表面积与体积比和多孔性，电纺丝所产生的纳米纤维能够向伤口持续释放药物和氧气。使用具有不同性质的不同类型的聚合物有助于增强纳米纤维和渗出物的吸收。纳米纤维似乎具有适用于伤口愈合的理想结构，并且与姜黄素结合使用，可以将姜黄素的抗炎和抗氧化特性融合到一种非常有效的伤口敷料中。使用合适的姜黄素溶剂和从纳米纤维中缓慢释放姜黄素有助于克服姜黄素已知的局限性，特别是其低稳定性和有限的生物利用度。在这里，我们回顾了通过电纺丝技术合成的含有姜黄素的合成纳米纤维在伤口愈合方面的研究。
