Reder M S, Mathog R H, Capps M J
Laryngoscope. 1977 Dec;87(12):2008-15. doi: 10.1288/00005537-197712000-00005.
In order to evaluate the relative sensitivity of caloric and sinusoidal angular acceleration tests, thermal and rotational stimuli were administered to cats rendered vestibulotoxic with streptomycin sulfate. Three groups of six cats each, receiving daily subcutaneous injections of saline, 100 mg/kg streptomycin or 200 mg/kg streptomycin, were administered optokinetic, caloric and sinusoidal stimuli. Vestibular responses were evaluated by changes in the total slow phase displacement of the eyes and frequency of nystagmic beats. The results demonstrated that the saline treated animals had a decrease in response consistent with habituation; whereas, experimental animals showed a marked, rapid abolition of eye movement. The decrease in response was greater for the larger dose of streptomycin. Caloric or sinusoidal acceleration tests were equally sensitive in monitoring the degree of nystagmic depression. The data suggested that sinusoidal acceleration tests could be easily applied to the clinical vestibular assessment of ototoxicity.
为了评估冷热试验和正弦角加速度试验的相对敏感性,对用硫酸链霉素造成前庭中毒的猫施加热刺激和旋转刺激。每组六只猫,共三组,分别每日皮下注射生理盐水、100mg/kg链霉素或200mg/kg链霉素,然后对其施加视动、冷热和正弦刺激。通过眼睛总慢相位移的变化和眼球震颤搏动频率来评估前庭反应。结果表明,用生理盐水处理的动物反应降低,这与习惯化一致;而实验动物则表现出明显、快速的眼球运动消失。链霉素剂量越大,反应降低越明显。冷热试验或正弦加速度试验在监测眼球震颤抑制程度方面同样敏感。数据表明,正弦加速度试验可轻松应用于耳毒性的临床前庭评估。