Elibol Birsen, Kilic Ulkan
Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Department of Medical Biology, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
Front Endocrinol (Lausanne). 2018 Oct 15;9:614. doi: 10.3389/fendo.2018.00614. eCollection 2018.
SIRT1 protein, a member of Silent Information Regulator 2 (Sir2) protein family, have gained considerable attention as epigenetic regulators for a great area in the human physiology. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, cardiovascular diseases, cancer and neurodegeneration. Here, we provide an overview of the association of the increasing level of SIRT1 protein for regulating some disease related conditions such as obesity, cardiovascular diseases and neurodegeneration. This review also provides a detailed molecular understanding of the interaction of the some basic molecules with increasing SIRT1 levels rather than reduction of the SIRT1 expression. In this context, the current approaches to enhancing the expression of SIRT1 points the importance of epigenetics in several age-related diseases to provide a healthy aging by developing novel therapies which can prevent or damp the progression of some diseases.
SIRT1蛋白是沉默信息调节因子2（Sir2）蛋白家族的成员，作为人类生理学诸多领域的表观遗传调节因子，已受到广泛关注。沉默调节蛋白表达的变化在包括代谢综合征、心血管疾病、癌症和神经退行性变在内的多种疾病中至关重要。在此，我们概述了SIRT1蛋白水平升高与调节某些疾病相关状况（如肥胖、心血管疾病和神经退行性变）之间的关联。本综述还详细阐述了一些基础分子与升高的SIRT1水平相互作用的分子机制，而非SIRT1表达降低的情况。在此背景下，当前增强SIRT1表达的方法凸显了表观遗传学在几种与年龄相关疾病中的重要性，通过开发可预防或减缓某些疾病进展的新疗法来实现健康衰老。
