摄入氨基甲酸酯类农药后的迟发性神经毒性。

Delayed neurotoxicity after ingestion of carbamate pesticide.

作者信息

Dickoff D J, Gerber O, Turovsky Z

出版信息

Neurology. 1987 Jul;37(7):1229-31. doi: 10.1212/wnl.37.7.1229.

DOI:10.1212/wnl.37.7.1229

Abstract

We studied a patient who ingested 27 gm (500 mg/kg) of carbaryl (1-naphthyl N-methylcarbamate), a popular carbamate pesticide. After he recovered from acute cholinergic toxicity, acute weakness of arms and legs was accompanied by electrophysiologic findings consistent with axonal peripheral neuropathy. Recovery began at 1 week and continued for 9 months. A similar delayed neuropathy has been described with organophosphates but not with carbamate insecticides.

摘要

我们研究了一名摄入27克（500毫克/千克）西维因（1-萘基N-甲基氨基甲酸酯）的患者，西维因是一种常用的氨基甲酸酯类杀虫剂。在他从急性胆碱能毒性中恢复后，手臂和腿部出现急性无力，并伴有与轴索性周围神经病一致的电生理表现。恢复在1周时开始，并持续了9个月。类似的迟发性神经病已在有机磷中毒中有所描述，但在氨基甲酸酯类杀虫剂中毒中未见报道。