Ventimiglia R, Greene M I, Geller H M
Proc Natl Acad Sci U S A. 1987 Jul;84(14):5073-7. doi: 10.1073/pnas.84.14.5073.
Hypothalamic neurons and cortical protoplasmic (type 1) astrocytes in dissociated cultures of rat brain express binding sites for antibodies specific for epitopes related to the beta-adrenergic receptor. Undifferentiated glial progenitor cells of the rat optic nerve do not detectably bind these antibodies, but both of the progeny [oligodendroglia and process-bearing (type 2) astrocytes] express immunologically identified beta-adrenergic receptors. Levels of receptor expression are variable: not all cells of each type express receptors nor is expression uniform on a given cell. The data suggest that cells of the central nervous system express beta-adrenergic receptors but that levels of expression may be determined by the differentiated state of the cells.
在大鼠脑的解离培养物中，下丘脑神经元和皮质原浆型（1型）星形胶质细胞表达与β-肾上腺素能受体相关表位特异性抗体的结合位点。大鼠视神经未分化的神经胶质祖细胞未检测到可与这些抗体结合，但这两种子代细胞（少突胶质细胞和有突起的2型星形胶质细胞）均表达经免疫鉴定的β-肾上腺素能受体。受体表达水平是可变的：并非每种类型的所有细胞都表达受体，并且在给定细胞上的表达也不均匀。数据表明，中枢神经系统的细胞表达β-肾上腺素能受体，但表达水平可能由细胞的分化状态决定。
