利用爱泼斯坦-巴尔病毒编码的p63/潜伏膜蛋白片段产生特异性细胞毒性T细胞。
Generation of specific cytotoxic T cells with a fragment of the Epstein-Barr virus-encoded p63/latent membrane protein.
作者信息
Thorley-Lawson D A, Israelsohn E S
出版信息
Proc Natl Acad Sci U S A. 1987 Aug;84(15):5384-8. doi: 10.1073/pnas.84.15.5384.
Abstract
Human B lymphocytes, transformed by the herpesvirus Epstein-Barr virus, are known to express a characteristic antigen(s) recognized by the cellular immune response. This structure has been termed lymphocyte-determined membrane antigen. Because of the significance of this structure in controlling Epstein-Barr virus infection in vivo, the molecular nature of lymphocyte-determined membrane antigen has been long sought. In this paper, we show that a sequence of 10 amino acids (residues 43-53) from the Epstein-Barr virus-encoded membrane protein p63/latent membrane protein can induce Epstein-Barr virus-specific cytotoxic T cells and, therefore, bears at least one of the lymphocyte-determined membrane antigenic determinants.
摘要
已知由疱疹病毒爱泼斯坦-巴尔病毒转化的人B淋巴细胞表达一种可被细胞免疫反应识别的特征性抗原。这种结构被称为淋巴细胞决定的膜抗原。由于这种结构在体内控制爱泼斯坦-巴尔病毒感染方面的重要性，人们长期以来一直在寻找淋巴细胞决定的膜抗原的分子性质。在本文中，我们表明，来自爱泼斯坦-巴尔病毒编码的膜蛋白p63/潜伏膜蛋白的一段10个氨基酸的序列（第43-53位氨基酸残基）可诱导爱泼斯坦-巴尔病毒特异性细胞毒性T细胞，因此，该序列至少携带一种淋巴细胞决定的膜抗原决定簇。
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