T淋巴细胞对EB病毒细胞毒性的HLA抗原相关限制
HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.
作者信息
Misko I S, Moss D J, Pope J H
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4247-50. doi: 10.1073/pnas.77.7.4247.
Abstract
The specificity of cytotoxic T cells generated in Epstein-Barr virus (EBV)-infected lymphocyte cultures was investigated, using a 51Cr release assay. Potent cytotoxic T cells with preferred specificity directed to antigens expressed on autologous lymphoblastoid cell line (LCL) target cells were present in 14-day cultures of lymphocytes from EBV-seropositive donors and not from seronegative donors. Moreover, the cytotoxic patterns obtained with a panel of HLA antigen-related and unrelated LCL target cells, supported by unlabeled target inhibition tests, strongly indicate that T cell cytotoxicity to EBV is restricted to HLA antigens.
摘要
使用铬-51释放试验，研究了在爱泼斯坦-巴尔病毒（EBV）感染的淋巴细胞培养物中产生的细胞毒性T细胞的特异性。在来自EBV血清阳性供体而非血清阴性供体的淋巴细胞14天培养物中，存在对自体淋巴母细胞系（LCL）靶细胞上表达的抗原具有优先特异性的强效细胞毒性T细胞。此外，一组HLA抗原相关和不相关的LCL靶细胞获得的细胞毒性模式，在未标记靶细胞抑制试验的支持下，强烈表明T细胞对EBV的细胞毒性受限于HLA抗原。
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