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1
HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.T淋巴细胞对EB病毒细胞毒性的HLA抗原相关限制
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4247-50. doi: 10.1073/pnas.77.7.4247.
2
Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines.伯基特淋巴瘤细胞系中I类人白细胞抗原及爱泼斯坦-巴尔病毒编码的潜伏膜蛋白的下调。
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4567-71. doi: 10.1073/pnas.84.13.4567.
3
Heterogeneity of allogeneic restriction of human cytotoxic T cell clones specific for Epstein Barr virus.针对爱泼斯坦-巴尔病毒的人细胞毒性T细胞克隆的同种异体限制的异质性。
J Immunol. 1982 Mar;128(3):1241-5.
4
Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid mice.人爱泼斯坦-巴尔病毒（EBV）特异性细胞毒性T淋巴细胞优先归巢至异种移植的C.B-17 scid/scid小鼠体内自体EBV诱导的B细胞淋巴增殖灶，并诱导其选择性消退。
J Exp Med. 1996 Mar 1;183(3):1215-28. doi: 10.1084/jem.183.3.1215.
5
Memory of Epstein-Barr virus-specific cytotoxic T cells in normal seropostive adults as revealed by an in vitro restimulation method.通过体外再刺激方法揭示正常血清阳性成年人中爱泼斯坦-巴尔病毒特异性细胞毒性T细胞的记忆
J Immunol. 1980 Oct;125(4):1426-31.
6
Recognition of autologous lymphoblastoid cells by cloned human T cells: inhibition of cytotoxicity by anti-HLA antibody but not by antibody to Epstein-Barr virus induced cell surface antigen.克隆化的人T细胞对自身淋巴母细胞样细胞的识别：抗HLA抗体可抑制细胞毒性，而抗爱泼斯坦-巴尔病毒诱导的细胞表面抗原的抗体则无此作用。
Hum Immunol. 1984 Apr;9(4):211-9. doi: 10.1016/0198-8859(84)90026-0.
7
Composite response of naive T cells to stimulation with the autologous lymphoblastoid cell line is mediated by CD4 cytotoxic T cell clones and includes an Epstein-Barr virus-specific component.幼稚T细胞对自体淋巴母细胞系刺激的复合反应由CD4细胞毒性T细胞克隆介导，并包括一个爱泼斯坦-巴尔病毒特异性成分。
Cell Immunol. 1991 Feb;132(2):295-307. doi: 10.1016/0008-8749(91)90029-b.
8
In vitro induction of HLA-restricted cytotoxic T lymphocytes against autologous Epstein-Barr Virus transformed B lymphoblastoid cell line.体外诱导针对自体爱泼斯坦-巴尔病毒转化的B淋巴母细胞系的HLA限制性细胞毒性T淋巴细胞。
J Immunol. 1981 May;126(5):1697-701.
9
Reactivation of Epstein-Barr virus-specific cytotoxic T cells by in vitro stimulation with the autologous lymphoblastoid cell line.通过用自体淋巴母细胞系进行体外刺激来重新激活爱泼斯坦-巴尔病毒特异性细胞毒性T细胞。
Int J Cancer. 1981 May 15;27(5):593-601. doi: 10.1002/ijc.2910270505.
10
Differentiation-dependent sensitivity of human B-cell-derived lines to major histocompatibility complex-restricted T-cell cytotoxicity.人B细胞系对主要组织相容性复合体限制的T细胞细胞毒性的分化依赖性敏感性。
Proc Natl Acad Sci U S A. 1986 Aug;83(15):5620-4. doi: 10.1073/pnas.83.15.5620.

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Association of HLA Compatibility and Decreased Liver Transplant Survival.人类白细胞抗原相容性与肝移植生存率降低的关联
Transplant Proc. 1988 Feb;20(1 Suppl 1):43-44.
2
The immunology of Epstein-Barr virus infection.爱泼斯坦-巴尔病毒感染的免疫学
Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):475-88. doi: 10.1098/rstb.2000.0784.
3
Functional analysis of the CD4(+) T-cell response to Epstein-Barr virus: T-cell-mediated activation of resting B cells and induction of viral BZLF1 expression.CD4(+) T细胞对爱泼斯坦-巴尔病毒反应的功能分析：T细胞介导的静止B细胞活化及病毒BZLF1表达的诱导
J Virol. 2000 Jul;74(14):6675-9. doi: 10.1128/jvi.74.14.6675-6679.2000.
4
Adoptive immunotherapy for Epstein-Barr virus-associated lymphoproliferative disorders complicating marrow allografts.针对异基因骨髓移植后并发的爱泼斯坦-巴尔病毒相关淋巴增殖性疾病的过继性免疫治疗。
Springer Semin Immunopathol. 1998;20(3-4):455-91. doi: 10.1007/BF00838055.
5
Epstein-Barr virus-transformed B cells, a potentially convenient source of autologous antigen-presenting cells for the propagation of certain human cytotoxic T lymphocytes.爱泼斯坦-巴尔病毒转化的B细胞，一种潜在的方便的自体抗原呈递细胞来源，用于某些人类细胞毒性T淋巴细胞的增殖。
Clin Diagn Lab Immunol. 1994 Nov;1(6):696-700. doi: 10.1128/cdli.1.6.696-700.1994.
6
Immune regulation in Epstein-Barr virus-associated diseases.爱泼斯坦-巴尔病毒相关疾病中的免疫调节
Microbiol Rev. 1995 Sep;59(3):387-405. doi: 10.1128/mr.59.3.387-405.1995.
7
Human leukocyte antigen-linked genetic controls for T cell-mediated cytotoxic response to mumps virus in humans.人类白细胞抗原相关的基因控制人类对腮腺炎病毒的T细胞介导的细胞毒性反应。
Infect Immun. 1982 Feb;35(2):600-4. doi: 10.1128/iai.35.2.600-604.1982.
8
Cell-mediated immunity against Epstein-Barr virus infected B lymphocytes.针对爱泼斯坦-巴尔病毒感染的B淋巴细胞的细胞介导免疫。
Springer Semin Immunopathol. 1982;5(1):63-73. doi: 10.1007/BF00201957.
9
Establishment of spontaneously outgrowing lymphoblastoid cell lines with Cyclosporin A.用环孢菌素A建立自发生长的淋巴母细胞样细胞系。
Med Microbiol Immunol. 1983;172(2):87-99. doi: 10.1007/BF02124509.
10
Clinical consequences of Epstein-Barr virus infection and possible control by an anti-viral vaccine.爱泼斯坦-巴尔病毒感染的临床后果及抗病毒疫苗的可能防控作用
Clin Exp Immunol. 1983 Aug;53(2):257-71.

本文引用的文献

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Long-term T-cell-mediated immunity to Epstein-Barr virus in man. IV. Development of T-cell memory in convalescent infectious mononucleosis patients.人类对EB病毒的长期T细胞介导免疫。IV. 恢复期传染性单核细胞增多症患者T细胞记忆的发展。
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Surface markers on human b and t lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte subpopulations.人类B淋巴细胞和T淋巴细胞的表面标志物。VI. 对细胞系的细胞毒性作为淋巴细胞亚群的功能标志物。
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Human cell-mediated cytotoxicity against modified target cells is restricted by HLA.人类细胞介导的针对修饰靶细胞的细胞毒性受人类白细胞抗原（HLA）限制。
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HLA restriction of cell-mediated lysis of influenza virus-infected human cells.流感病毒感染的人类细胞的细胞介导裂解的HLA限制
Nature. 1977 Dec 8;270(5637):524-6. doi: 10.1038/270524a0.
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HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus.人类细胞毒性T细胞对流感病毒反应特异性的HLA连锁基因控制
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Y-antigen killing by T cells of women is restricted by HLA.女性T细胞对Y抗原的杀伤作用受HLA限制。
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10
Absence of allogeneic restriction in human T-cell-mediated cytotoxicity to Epstein-Barr virus-infected target cells. Demonstration of an HLA-linked control at the effector level.人类T细胞介导的对爱泼斯坦-巴尔病毒感染靶细胞的细胞毒性中同种异体限制的缺失。效应水平上HLA连锁控制的证明。
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T淋巴细胞对EB病毒细胞毒性的HLA抗原相关限制

HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.

作者信息

Misko I S, Moss D J, Pope J H

出版信息

Proc Natl Acad Sci U S A. 1980 Jul;77(7):4247-50. doi: 10.1073/pnas.77.7.4247.

DOI:10.1073/pnas.77.7.4247
PMID:6254017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC349809/
Abstract

The specificity of cytotoxic T cells generated in Epstein-Barr virus (EBV)-infected lymphocyte cultures was investigated, using a 51Cr release assay. Potent cytotoxic T cells with preferred specificity directed to antigens expressed on autologous lymphoblastoid cell line (LCL) target cells were present in 14-day cultures of lymphocytes from EBV-seropositive donors and not from seronegative donors. Moreover, the cytotoxic patterns obtained with a panel of HLA antigen-related and unrelated LCL target cells, supported by unlabeled target inhibition tests, strongly indicate that T cell cytotoxicity to EBV is restricted to HLA antigens.

摘要

使用铬-51释放试验，研究了在爱泼斯坦-巴尔病毒（EBV）感染的淋巴细胞培养物中产生的细胞毒性T细胞的特异性。在来自EBV血清阳性供体而非血清阴性供体的淋巴细胞14天培养物中，存在对自体淋巴母细胞系（LCL）靶细胞上表达的抗原具有优先特异性的强效细胞毒性T细胞。此外，一组HLA抗原相关和不相关的LCL靶细胞获得的细胞毒性模式，在未标记靶细胞抑制试验的支持下，强烈表明T细胞对EBV的细胞毒性受限于HLA抗原。