慢性乙醇暴露对大鼠腺苷酸环化酶活性的影响。

Effects of chronic ethanol exposure on adenylate cyclase activities in the rat.

作者信息

Rabin R A, Baker R C, Deitrich R A

出版信息

Pharmacol Biochem Behav. 1987 Apr;26(4):693-7. doi: 10.1016/0091-3057(87)90598-3.

Abstract

The effects of chronic ethanol administration on striatal and cerebellar adenylate cyclase systems were investigated in the rat. The chronic ethanol treatment resulted in behavioral tolerance, but no difference in the sensitivity of adenylate cyclase to in vitro ethanol was observed. In one set of experiments using 173-195 g rats, GTP-, dopamine- and NaF-stimulated adenylate cyclase activities in the striatum were higher in rats chronically treated with ethanol when compared to animals pair-fed the liquid diet. However, no difference in adenylate cyclase activity was observed in cerebellar or striatal tissues when larger rats (280-385 g) were used. In conclusion, an adaptive change in activation of adenylate cyclase by in vitro ethanol does not occur after chronic ethanol treatment. The observed changes in enzyme activity measured in the absence of in vitro ethanol do not appear to be a simple, direct effect of chronic ethanol treatment.

摘要

研究了慢性给予乙醇对大鼠纹状体和小脑腺苷酸环化酶系统的影响。慢性乙醇处理导致行为耐受性，但未观察到腺苷酸环化酶对体外乙醇的敏感性有差异。在一组使用体重173 - 195克大鼠的实验中，与接受液体饮食配对喂养的动物相比，长期用乙醇处理的大鼠纹状体中由GTP、多巴胺和氟化钠刺激的腺苷酸环化酶活性更高。然而，当使用较大的大鼠（280 - 385克）时，在小脑或纹状体组织中未观察到腺苷酸环化酶活性有差异。总之，慢性乙醇处理后，体外乙醇对腺苷酸环化酶激活的适应性变化不会发生。在不存在体外乙醇的情况下测得的酶活性变化似乎不是慢性乙醇处理的简单直接效应。