Lucchi L, Govoni S, Trabucchi M
Alcohol. 1984 Jul-Aug;1(4):263-7. doi: 10.1016/0741-8329(84)90047-8.
The effect of chronic ethanol consumption on adenylate cyclase activity was measured in striatal membranes derived from aged male rats. The results indicate that the cyclic AMP generating system of old rats has a different sensitivity to ethanol effect compared to the adult animals. In young animals the basal adenylate cyclase activity was enhanced by alcohol consumption while the DA stimulated cyclic AMP production was reduced. In contrast, in 24 months old rats ethanol reduced the basal adenylyl cyclase and enhanced the response to DA indicating a supersensitivity of adenylate cyclase linked DA receptors. This observation was further supported by 3H-Spiperone binding studies. In fact, a higher Bmax was measured in striatal membranes of aged ethanol-dependent rats in comparison to control.
测定了长期乙醇摄入对老年雄性大鼠纹状体膜中腺苷酸环化酶活性的影响。结果表明，与成年动物相比，老年大鼠的环磷酸腺苷生成系统对乙醇作用具有不同的敏感性。在幼龄动物中，饮酒可增强基础腺苷酸环化酶活性，而多巴胺刺激的环磷酸腺苷生成则减少。相反，在24月龄大鼠中，乙醇降低了基础腺苷酸环化酶活性，并增强了对多巴胺的反应，表明与腺苷酸环化酶相关的多巴胺受体超敏。3H-司哌罗宁结合研究进一步支持了这一观察结果。事实上，与对照组相比，老年乙醇依赖大鼠纹状体膜中的最大结合容量（Bmax）更高。
