School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, P. R. China.
Chem Commun (Camb). 2018 Nov 13;54(91):12871-12874. doi: 10.1039/c8cc06140h.
Celastrol is one of the most studied natural products. Our studies show for the first time that celastrol can bind to its target protein via specific noncovalent interactions that position celastrol next to the thiol group of the reactive cysteine for reversible covalent bond formation. Such specific noncovalent interactions confer celastrol binding specificity and demonstrate the feasibility of improving the efficacy and selectivity of celastrol for therapeutic applications.
雷公藤红素是研究最多的天然产物之一。我们的研究首次表明，雷公藤红素可以通过特定的非共价相互作用与靶蛋白结合，使雷公藤红素位于反应性半胱氨酸的巯基旁边，以便进行可逆的共价键形成。这种特异性的非共价相互作用赋予了雷公藤红素结合的特异性，并证明了提高雷公藤红素治疗应用的疗效和选择性的可行性。
