血清对氧磷酶-1 活性与轻至中度饮酒有关：PREVEND 队列研究。

Serum paraoxonase-1 activity is associated with light to moderate alcohol consumption: the PREVEND cohort study.

机构信息

Departments of Endocrinology.

Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

出版信息

Am J Clin Nutr. 2018 Dec 1;108(6):1283-1290. doi: 10.1093/ajcn/nqy217.

DOI:10.1093/ajcn/nqy217

PMID:30376039

Abstract

BACKGROUND

Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidative properties, which may protect against the development of cardiovascular disease. Alcohol consumption increases HDL cholesterol, but the extent to which alcohol consumption gives rise to higher serum PON-1 activity is uncertain.

OBJECTIVE

In a population-based study, we determined the relation of serum PON-1 activity with alcohol consumption when taking account of HDL cholesterol and apolipoprotein A-I (apoA-I), its major apolipoprotein.

DESIGN

A cross-sectional study was performed in 8224 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. Alcohol consumption was categorized as 1) no/rarely (25.3%); 2) 0.1-10 g/d (49.3%); 3) 10-30 g/d (20.1%); and 4) >30 g/d (5.2%) with 1 drink equivalent to 10 g alcohol. Serum PON-1 activity was measured as its arylesterase activity (phenyl acetate as substrate).

RESULTS

Median serum PON-1 activity was 50.8, 53.1, 54.4, and 55.7 U/L in the 4 categories of alcohol consumption, respectively (P < 0.001). Its increase paralleled the increments in HDL cholesterol and apoA-I. Notably, there was no further increase in PON-1 activity, HDL cholesterol, and apoA-I when alcohol consumption was increased from 10-30 g/d to >30 g/d. Multivariable linear regression analysis demonstrated that PON-1 activity was related to alcohol consumption independently from clinical covariates, high sensitivity C-reactive protein, and lipid concentrations, including HDL cholesterol (P < 0.001 for each category of alcohol consumption with no alcohol consumption as the reference category). Notably, as inferred from standardized β-coefficients, there was no difference in PON-1 activity between 10-30 g alcohol/d and >30 g alcohol/d.

CONCLUSIONS

Alcohol consumption is associated with an increase in serum PON-1 activity, but its effect seems to reach a plateau with alcohol consumption of 10-30 g/d.

摘要

背景

对氧磷酶 1（PON-1）是一种高密度脂蛋白（HDL）相关的酶，具有抗氧化特性，可能有助于预防心血管疾病的发生。饮酒会增加 HDL 胆固醇，但饮酒对血清 PON-1 活性的影响程度尚不确定。

目的

在一项基于人群的研究中，我们在考虑 HDL 胆固醇和载脂蛋白 A-I（apoA-I）的情况下，确定了血清 PON-1 活性与酒精消费之间的关系，apoA-I 是其主要载脂蛋白。

设计

在预防肾脏和血管终末期疾病（PREVEND）队列的 8224 名参与者中进行了一项横断面研究。饮酒分为 1) 不/很少（25.3%）；2) 0.1-10 g/d（49.3%）；3) 10-30 g/d（20.1%）和 4) >30 g/d（5.2%），1 份酒当量相当于 10 g 酒精。血清 PON-1 活性作为其芳基酯酶活性（苯乙酸作为底物）进行测量。

结果

在酒精消费的 4 个类别中，血清 PON-1 活性中位数分别为 50.8、53.1、54.4 和 55.7 U/L（P<0.001）。其增加与 HDL 胆固醇和 apoA-I 的增加平行。值得注意的是，当酒精摄入量从 10-30 g/d 增加到>30 g/d 时，PON-1 活性、HDL 胆固醇和 apoA-I 并没有进一步增加。多变量线性回归分析表明，PON-1 活性与酒精消费独立于临床协变量、高敏 C 反应蛋白和脂质浓度（包括 HDL 胆固醇有关，每个酒精消费类别与不饮酒作为参考类别相比，P<0.001）。值得注意的是，根据标准化β系数推断，10-30 g 酒精/d 和>30 g 酒精/d 之间的 PON-1 活性没有差异。