Quiroga-Morales Luis Aarón, Sat-Muñoz Daniel, Martínez-Herrera Brenda Eugenia, Alcántara-Cadillo Rodolfo Renzo, Macías-López Griselda Guadalupe, García-Cobián Teresa Arcelia, Bañuelos-Rizo Mauricio, Balderas-Peña Luz Ma. Adriana
Rev Med Inst Mex Seguro Soc. 2018 Oct 25;56(3):246-254.
There is a relationship between obesity and the development of breast cancer; adipocytokines are among the mechanisms related.
To describe the impact of obesity in leptin, adiponectin, resistin and tumor necrosis factor-alpha (TNF-alpha) serum levels in women with breast cancer (BC) and benign breast disease (BBD).
A cross-sectional study was carried out with a sample of 54 individuals divided into two groups: BC (n = 27) and BBD (n = 27). Serum levels of leptin, adiponectin, resistin and TNF-alpha were determined. Body mass index (BMI) was calculated. Statistical analysis included mean, standard deviation, median and interquartile range; the differences between groups were determined by Student´s t test, Mann-Whitney U and Kruskall Wallis test to identify differences between the groups.
We didn’t find any significant differences related to anthropometric characteristics between BC and BBD groups, or to leptin, adiponectin, resistin and TNF-alpha serum levels (p = NS). We found higher leptin serum levels in obese women with BBD compared with non-obese women with BC (med 22.26 versus 4.34 ng/mL; p = 0.028). Adiponectin serum levels in non-obese women from the BC group were higher than serum levels found in non-obese women with BBD (med 7.10 versus 2.22 ng/mL; p = 0.038)
We found higher leptin serum levels and lower adiponectin serum levels in BBD women than BC women in this population with high frequency of obesity.
肥胖与乳腺癌的发生发展之间存在关联；脂肪细胞因子是其中相关的机制之一。
描述肥胖对乳腺癌（BC）和乳腺良性疾病（BBD）女性血清瘦素、脂联素、抵抗素和肿瘤坏死因子-α（TNF-α）水平的影响。
进行了一项横断面研究，样本为54人，分为两组：BC组（n = 27）和BBD组（n = 27）。测定血清瘦素、脂联素、抵抗素和TNF-α水平。计算体重指数（BMI）。统计分析包括均值、标准差、中位数和四分位间距；通过学生t检验、曼-惠特尼U检验和克鲁斯卡尔-沃利斯检验确定组间差异，以识别各组之间的差异。
我们未发现BC组和BBD组在人体测量特征方面，或在瘦素、脂联素、抵抗素和TNF-α血清水平方面存在任何显著差异（p = 无显著性差异）。我们发现，患有BBD的肥胖女性的血清瘦素水平高于患有BC的非肥胖女性（中位数22.26对4.34 ng/mL；p = 0.028）。BC组非肥胖女性的脂联素血清水平高于患有BBD的非肥胖女性的血清水平（中位数7.10对2.22 ng/mL；p = 0.038）。
在这个肥胖发生率较高的人群中，我们发现BBD女性的血清瘦素水平高于BC女性，而脂联素血清水平低于BC女性。
