Tokgöz Mehmet Ali, Atik Osman Şahap, Esendağlı Güldal, Öğüt Betül, Bozkurt Hasan Hüseyin
Department of Orthopedics and Traumatology, Medicine Faculty of Gazi University, 06500 Beşevler, Ankara, Turkey.
Eklem Hastalik Cerrahisi. 2018 Dec;29(3):152-8. doi: 10.5606/ehc.2018.007.
This study aims to investigate the role of subchondral trabecular bone thickness in the mechanism of knee osteoarthritis and the correlation of osteoarthritis and osteoporosis pathogenesis.
The study included 62 patients (9 males, 53 females; mean age 66.7 years; range, 50 to 84 years) with osteoarthritis. All radiographs were evaluated according to Kellgren and Lawrence classification. The bone mineral density of the patients was measured and bone samples were collected from all patients included in the study during the surgical procedure and investigated pathologically.
Osteoarthritis grade and trabecular bone thickness were correlated with each other. Trabecular thickness rate was higher in patients with severe osteoarthritis, whereas trabecular thickness rate was statistically significantly lower than the mean in patients with mild osteoarthritis (p=0.045).
Trabecular thickness rate was significantly lower in the mild grade of osteoarthritis compared to the severe grade. As the level of osteoarthritis increased, the number of patients with osteoporosis decreased.
本研究旨在探讨软骨下小梁骨厚度在膝关节骨关节炎发病机制中的作用以及骨关节炎与骨质疏松症发病机制之间的相关性。
该研究纳入了62例骨关节炎患者（9例男性，53例女性；平均年龄66.7岁；范围为50至84岁）。所有X线片均根据凯尔格伦和劳伦斯分类法进行评估。测量患者的骨密度，并在手术过程中从纳入研究的所有患者中采集骨样本进行病理检查。
骨关节炎分级与小梁骨厚度相互关联。重度骨关节炎患者的小梁厚度率较高，而轻度骨关节炎患者的小梁厚度率在统计学上显著低于平均值（p = 0.045）。
与重度骨关节炎相比，轻度骨关节炎的小梁厚度率显著更低。随着骨关节炎程度的增加，骨质疏松症患者的数量减少。
Zotero 插件