胆囊切除术对膝骨关节炎发生的影响。

Effect of Cholecystectomy on the Occurrence of Knee Osteoarthritis.

作者信息

Zeng Ling-Yuan, Yang Shu-Yan, Zhang Zhi-Qiang, Wang Tao, Wang Yu-Ze, Wei Xiao-Chun

机构信息

Department of Orthopaedic Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Department of Blood Transfusion, The Second Hospital of Shanxi Medical University, Taiyuan, China.

出版信息

Orthop Surg. 2020 Jun;12(3):756-760. doi: 10.1111/os.12671. Epub 2020 Jun 1.

DOI:10.1111/os.12671

PMID:32476289

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7307220/

Abstract

OBJECTIVE

To evaluate the effect of cholecystectomy on the occurrence of knee osteoarthritis (KOA).

METHODS

The present study was a case-control study with a retrospective, cross-sectional, and longitudinal study design. The clinical data for knee osteoarthritis in the Second Hospital of Shanxi Medical University from January 2016 to September 2018 was analyzed. Clinical data, including gender, age, height, weight, smoking, alcohol abuse, prior medical history, and previous surgical history, were recorded. A logistic regression model was used for the univariate and multivariate analysis.

RESULTS

A total of 1659 patients with KOA (KOA group) and 1195 limb fracture patients (control group) were included in this study. Among the 1659 patients with KOA, 388 patients were male and 1271 were female, while among the 1195 patients in the control group, 638 patients were male and 557 patients were female. The period between cholecystectomy and knee osteoarthritis onset ranged from 0.5 years to 17 years; the average interval time was 8.73 ± 2.11 years. The age at disease onset was significantly older when compared to the control group, while the body mass index in the KOA group was significantly higher when compared to the control group (P < 0.05). There were 97 patients undergoing cholecystectomy in the KOA group and there were 15 patients undergoing cholecystectomy in the control group. The proportion of cholecystectomy in the two groups was statistically significant. After the univariate analysis, there was a statistically significant difference in distribution between the two groups (P < 0.05). The multivariate logistic regression analysis revealed that there was a significant difference in the distribution of these two groups (P < 0.05), indicating that cholecystectomy is associated with the occurrence of KOA.

CONCLUSION

There is a close relationship between cholecystectomy and KOA. However, the specific mechanism remains unknown and should be further researched.

摘要

目的

评估胆囊切除术对膝骨关节炎（KOA）发生的影响。

方法

本研究为病例对照研究，采用回顾性、横断面和纵向研究设计。分析了山西医科大学第二医院2016年1月至2018年9月膝骨关节炎的临床资料。记录了临床数据，包括性别、年龄、身高、体重、吸烟、酗酒、既往病史和既往手术史。采用逻辑回归模型进行单因素和多因素分析。

结果

本研究共纳入1659例KOA患者（KOA组）和1195例肢体骨折患者（对照组）。在1659例KOA患者中，男性388例，女性1271例；而在对照组的1195例患者中，男性638例，女性557例。胆囊切除术后至膝骨关节炎发病的时间为0.5年至17年；平均间隔时间为8.73±2.11年。与对照组相比，发病年龄显著更大，而KOA组的体重指数显著更高（P<0.05）。KOA组有97例患者接受了胆囊切除术，对照组有15例患者接受了胆囊切除术。两组胆囊切除术的比例具有统计学意义。单因素分析后，两组之间的分布存在统计学差异（P<0.05）。多因素逻辑回归分析显示，两组的分布存在显著差异（P<0.05），表明胆囊切除术与KOA的发生有关。