School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
School of Exercise and Health, Guangzhou Sport University, Guangzhou, China.
Front Endocrinol (Lausanne). 2023 May 23;14:1159393. doi: 10.3389/fendo.2023.1159393. eCollection 2023.
Articular cartilage degeneration has been proved to cause a variety of joint diseases, among which osteoarthritis is the most typical. Osteoarthritis is characterized by articular cartilage degeneration and persistent pain, which affects the quality of life of patients as well as brings a heavy burden to society. The occurrence and development of osteoarthritis is related to the disorder of the subchondral bone microenvironment. Appropriate exercise can improve the subchondral bone microenvironment, thus playing an essential role in preventing and treating osteoarthritis. However, the exact mechanism whereby exercise improves the subchondral bone microenvironment remains unclear. There is biomechanical interaction as well as biochemical crosstalk between bone and cartilage. And the crosstalk between bone and cartilage is the key to bone-cartilage homeostasis maintenance. From the perspective of biomechanical and biochemical crosstalk between bone and cartilage, this paper reviews the effects of exercise-mediated bone-cartilage crosstalk on the subchondral bone microenvironment, aiming to provide a theoretical basis for the prevention and treatment of degenerative bone diseases.
关节软骨退变已被证实可引起多种关节疾病，其中骨关节炎最为典型。骨关节炎的特征为关节软骨退变和持续性疼痛，这不仅影响患者的生活质量，也给社会带来沉重负担。骨关节炎的发生发展与软骨下骨微环境紊乱有关。适当的运动可以改善软骨下骨微环境，从而在预防和治疗骨关节炎方面发挥重要作用。然而，运动改善软骨下骨微环境的确切机制尚不清楚。骨与软骨之间存在生物力学相互作用和生化串扰，而骨与软骨之间的串扰是维持骨-软骨平衡的关键。本文从骨-软骨生物力学和生化串扰的角度，综述了运动介导的骨-软骨串扰对软骨下骨微环境的影响，旨在为退行性骨病的防治提供理论依据。
