[The Expression and Significance of c-myc and bcat1 in Cervical Cancer].

OBJECTIVE

To explore the relationship between c-myc and bcat1 expression and the occurrence, development and clinical features of cervical cancer.

METHODS

The expression level of c-myc and bcat1 were detected in 30 cases of normal cervical tissues, 30 cases of CIN tissues, 40 cases of cervical squamous carcinoma tissues and 40 cases of cervical adenocarcinoma tissues by immunohistochemistry; Conduct a Spearman rank correlation analysis between c-myc and bcat1 expressions; Analyze the relationship between the expression of both genes and clinicopathological factors of cervical cancer.

RESULTS

The positive rates of c-myc expression were 16.7% (5/30) in normal cervical tissues, 43.3% (13/30) in CIN tissues and 73.8% (59/80) in cervical cancer tissues, the positive rates of bcat1 expression were 10.0% (3/30) in normal cervical tissues, 23.3% (7/30) in CIN tissues and 52.5% (42/80) in cervical cancer tissues. The rank correlation index between c-myc and bcat1 is respectively 0.773 (=0.000) in cervical squamous carcinoma and 0.369 (=0.019) in adenocarcinoma. The positive expression rate of c-myc was related to the pathological type of cancer tissue (adenocarcinoma/squamous cell carcinoma), the degree of tumor tissue differentiation, the depth of interstitial infiltration, and the presence or absence of vascular invasion (<0.05). The positive expression rate of bcat1 was related to the degree of tumor differentiation, vascular invasion and Ki67 index (<0.05).

CONCLUSION

The high expression of c-myc may promote the invasion and metastasis of cervical cancer, and the high expression of bcat1 may promote the proliferation, invasion and metastasis of cervical cancer, which may have a synergistic effect in the pathogenesis of cervical cancer.