Department of Pharmacy, Hazara University, Mansehra 21300, Pakistan.
Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan.
Molecules. 2022 Oct 23;27(21):7175. doi: 10.3390/molecules27217175.
Polydatin or 3--β-d-resveratrol-glucopyranoside (PD), a stilbenoid component of (Polygonaceae), has a variety of biological roles. In traditional Chinese medicine, extracts are used for the treatment of infections, inflammation, and cardiovascular disorders. Polydatin possesses a broad range of biological activities including antioxidant, anti-inflammatory, anticancer, and hepatoprotective, neuroprotective, and immunostimulatory effects. Currently, a major proportion of the population is victimized with cervical lung cancer, ovarian cancer and breast cancer. PD has been recognized as a potent anticancer agent. PD could effectively inhibit the migration and proliferation of ovarian cancer cells, as well as the expression of the PI3K protein. The malignancy of lung cancer cells was reduced after PD treatments via targeting caspase 3, arresting cancer cells at the S phase and inhibiting NLRP3 inflammasome by downregulation of the NF-κB pathway. This ceases cell cycle, inhibits VEGF, and counteracts ROS in breast cancer. It also prevents cervical cancer by regulating epithelial-to-mesenchymal transition (EMT), apoptosis, and the C-Myc gene. The objective of this review is thus to unveil the polydatin anticancer potential for the treatment of various tumors, as well as to examine the mechanisms of action of this compound.
虎杖苷（PD）是蓼科植物中的一种白藜芦醇糖苷，具有多种生物学作用。在传统中药中，虎杖提取物用于治疗感染、炎症和心血管疾病。虎杖苷具有广泛的生物学活性，包括抗氧化、抗炎、抗癌、保肝、神经保护和免疫刺激作用。目前，很大一部分人口受到宫颈癌、卵巢癌和乳腺癌的影响。PD 已被认为是一种有效的抗癌药物。PD 可有效抑制卵巢癌细胞的迁移和增殖，以及 PI3K 蛋白的表达。PD 通过靶向半胱天冬酶 3、将癌细胞阻滞在 S 期以及通过下调 NF-κB 通路抑制 NLRP3 炎性小体，降低肺癌细胞的恶性程度。PD 可以阻止细胞周期、抑制 VEGF 和清除 ROS，从而治疗乳腺癌。它还通过调节上皮-间充质转化（EMT）、细胞凋亡和 C-Myc 基因来预防宫颈癌。因此，本综述的目的是揭示虎杖苷治疗各种肿瘤的抗癌潜力，并研究该化合物的作用机制。
