Cesaretti Manuela, Addeo Pietro, Schiavo Luigi, Anty Rodolphe, Iannelli Antonio
Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, AP-HP, Clichy, France.
Department of Nanophysics, Italian Institute of Technology, Genova, Italy.
Liver Transpl. 2019 Mar;25(3):500-509. doi: 10.1002/lt.25379.
The growing number of patients on waiting lists for liver transplantation and the shortage of organs have forced many centers to adopt extended criteria for graft selection, moving the limit of acceptance for marginal livers. Steatotic grafts that were, in the past, considered strictly unacceptable for transplantation because of the high risk of early nonfunction are now considered as a potential resource for organ implementation. Several methods to diagnose, measure, classify, and stage steatosis exist, but none can be considered qualitatively and quantitatively "the ideal method" to date. Clinical, biological, and imaging data can be very helpful to estimate graft steatosis, but histology still remains the gold standard. There is an increasing need for rapid and reliable tools to assess graft steatosis. Herein, we present a comprehensive review of the approaches that are currently used to quantify steatosis in liver grafts.
等待肝移植的患者数量不断增加以及器官短缺，迫使许多中心采用更宽泛的移植物选择标准，放宽了对边缘性肝脏的接受限度。过去因早期无功能风险高而被认为绝对不适合移植的脂肪变性移植物，如今被视为器官移植的潜在资源。目前存在多种诊断、测量、分类和分期脂肪变性的方法，但迄今为止，尚无一种方法能在定性和定量方面被视为“理想方法”。临床、生物学和影像学数据对评估移植物脂肪变性非常有帮助，但组织学仍是金标准。对快速且可靠的移植物脂肪变性评估工具的需求日益增加。在此，我们对目前用于量化肝移植物脂肪变性的方法进行全面综述。
