Department of Chemistry, Yunnan Normal University, Kunming 650500, China.
College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.
Molecules. 2018 Oct 29;23(11):2802. doi: 10.3390/molecules23112802.
Metal-organic frameworks (MOFs) have recently attracted considerable attention because of their fascinating structures and intriguing potential applications in diverse areas. In this study, we developed a novel method for determination of enantiomeric excess () of (±)-1,1'-bi-2-naphthol by solid-phase extraction (SPE) using a chiral MOF, Co(l-tyr), as sorbent. After optimization of the experimental conditions, a good linear relationship between the and the absorbance of the eluate (² = 0.9984) was obtained and the standard curve was established at the concentration of 3 mmol L¹. The values of (±)-1,1'-bi-2-naphthol samples can be rapidly calculated using the standard curve after determination of the absorbance of the eluate. The method showed good accuracy, with an average error of 2.26%, and is promising for analysis.
金属-有机骨架（MOFs）因其迷人的结构和在各个领域的潜在应用而受到广泛关注。在这项研究中，我们开发了一种使用手性 MOF [Co(l-tyr)]（l-tyrCo）作为吸附剂的固相萃取（SPE）测定（±）-1,1'-联-2-萘酚对映体过量（ee）的新方法。在优化实验条件后，获得了 ee 与洗脱液吸光度之间的良好线性关系（² = 0.9984），并在 3 mmol L¹浓度下建立了标准曲线。通过测定洗脱液的吸光度，可以使用标准曲线快速计算（±）-1,1'-联-2-萘酚样品的 ee 值。该方法具有良好的准确性，平均误差为 2.26%，有望用于 ee 分析。
