• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

羟基磷灰石结合分子的构效关系（SAR）

Structure-activity relationships (SAR) of hydroxyapatite-binding molecules.

作者信息

Myers H M

出版信息

Calcif Tissue Int. 1987 Jun;40(6):344-8. doi: 10.1007/BF02556697.

DOI:10.1007/BF02556697
PMID:3038282
Abstract

Carboxyl-containing molecules can bind to HA with sufficient affinity to prevent the uptake of AZ by this mineral. Structural features that favor binding can be discerned. Isolated carboxyls are inactive; adjacent dicarboxylic functions are marginally active. Crowding of oxygens in the form of vicinal carboxyls or hydroxyls contributes the property of HA binding ability. This property exhibits gradation in magnitude and the variation can be correlated with structural features of the carboxyl-containing molecule. Phospho functions are generally more powerful contributors to HA binding property than are carboxyls.

摘要

含羧基的分子能够以足够的亲和力与透明质酸（HA）结合，从而阻止这种矿物质对阿霉素（AZ）的摄取。可以识别出有利于结合的结构特征。孤立的羧基没有活性；相邻的二羧酸官能团活性微弱。以邻位羧基或羟基形式存在的氧原子密集排列有助于形成与HA的结合能力。这种性质在程度上呈现出渐变，并且这种变化可以与含羧基分子的结构特征相关联。磷酸官能团对HA结合性质的贡献通常比羧基更强。

相似文献

1
Structure-activity relationships (SAR) of hydroxyapatite-binding molecules.羟基磷灰石结合分子的构效关系（SAR）
Calcif Tissue Int. 1987 Jun;40(6):344-8. doi: 10.1007/BF02556697.
2
Adsorption of molecules of biological interest onto hydroxyapatite.具有生物学意义的分子在羟基磷灰石上的吸附。
Calcif Tissue Int. 1984 Jan;36(1):48-59. doi: 10.1007/BF02405293.
3
Adhesion of carboxylate cements to hydroxyapatite. I. The effect of the structure of aliphatic carboxylates on their uptake by hydroxyapatite.
Biomaterials. 1986 Nov;7(6):438-40. doi: 10.1016/0142-9612(86)90031-1.
4
Interaction of calcium ions and salivary acidic proline-rich proteins with hydroxyapatite. A possible aspect of inhibition of hydroxyapatite formation.钙离子与富含脯氨酸的唾液酸性蛋白与羟基磷灰石的相互作用。抑制羟基磷灰石形成的一个可能方面。
Biochem J. 1983 Jul 1;213(1):11-20. doi: 10.1042/bj2130011.
5
Adsorption and orientation of tetracycline on hydroxyapatite.
Calcif Tissue Int. 1991 May;48(5):362-7. doi: 10.1007/BF02556156.
6
Characterization of the bisphosphonate recognition site on hydroxyapatite using radioligand binding techniques with [14C]citric acid.使用含[14C]柠檬酸的放射性配体结合技术对羟基磷灰石上双膦酸盐识别位点进行表征。
Calcif Tissue Int. 1993 May;52(5):372-7. doi: 10.1007/BF00310202.
7
The effect of phosphatidylserine on in vitro hydroxyapatite growth and proliferation.磷脂酰丝氨酸对体外羟基磷灰石生长和增殖的影响。
Calcif Tissue Int. 1991 Sep;49(3):193-6. doi: 10.1007/BF02556117.
8
Orientation of adsorbed alizarin red S on hydroxyapatite.
Calcif Tissue Int. 1982;34 Suppl 2:S57-61.
9
Calcium(II)-mediated doubling of alizarin adsorption in vitro.钙离子（II）介导的茜素体外吸附量加倍。
Arch Oral Biol. 1981;26(6):537-9. doi: 10.1016/0003-9969(81)90013-3.
10
The effect of fluoride on the uptake of albumin by hydroxyapatite.
Caries Res. 1982;16(4):282-6. doi: 10.1159/000260610.

引用本文的文献

1
Bone-specific drug delivery systems: approaches via chemical modification of bone-seeking agents.骨特异性药物递送系统：通过对趋骨剂进行化学修饰的方法。
Clin Pharmacokinet. 2003;42(15):1319-30. doi: 10.2165/00003088-200342150-00002.
2
Relationship between physicochemical and osteotropic properties of bisphosphonic derivatives: rational design for osteotropic drug delivery system (ODDS).双膦酸衍生物的物理化学性质与促骨特性之间的关系：促骨药物递送系统（ODDS）的合理设计
Pharm Res. 2001 May;18(5):646-51. doi: 10.1023/a:1011033326980.
3
Characterization of the bisphosphonate recognition site on hydroxyapatite using radioligand binding techniques with [14C]citric acid.

本文引用的文献

1
Interaction of some serum proteins with hydroxylapatite and other materials.一些血清蛋白与羟基磷灰石及其他材料的相互作用。
J Biomed Mater Res. 1980 Nov;14(6):705-12. doi: 10.1002/jbm.820140602.
2
Adsorption of the antibiotic actinobolin by hydroxyapatite.羟基磷灰石对抗生素放线杀菌素的吸附作用。
Arch Oral Biol. 1980;25(6):431-4. doi: 10.1016/0003-9969(80)90010-2.
3
Orientation of adsorbed alizarin red S on hydroxyapatite.
Calcif Tissue Int. 1982;34 Suppl 2:S57-61.
使用含[14C]柠檬酸的放射性配体结合技术对羟基磷灰石上双膦酸盐识别位点进行表征。
Calcif Tissue Int. 1993 May;52(5):372-7. doi: 10.1007/BF00310202.
4
The effects of serum and human albumin on calcium hydroxyapatite crystal growth.血清和人白蛋白对羟基磷灰石晶体生长的影响。
Biochem J. 1990 Mar 15;266(3):863-8.
5
The effect of phosphatidylserine on in vitro hydroxyapatite growth and proliferation.磷脂酰丝氨酸对体外羟基磷灰石生长和增殖的影响。
Calcif Tissue Int. 1991 Sep;49(3):193-6. doi: 10.1007/BF02556117.
4
The dissolution kinetics of hydroxyapatite in the presence of kink poisons.扭折毒存在下羟基磷灰石的溶解动力学
J Dent Res. 1966 Nov-Dec;45(6):1775-83. doi: 10.1177/00220345660450063201.
5
Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.酸性蛋白质与晶体之间的相互作用：生物矿化中的立体化学要求。
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4110-4. doi: 10.1073/pnas.82.12.4110.
6
Precipitation of calcium phosphates from electrolyte solutions. V. The influence of citrate ions.从电解质溶液中沉淀磷酸钙。V. 柠檬酸根离子的影响。
Calcif Tissue Int. 1979 Oct 31;28(2):131-6. doi: 10.1007/BF02441231.
7
An in vitro and in vivo investigation of mellitate and ethane-1-hydroxy-1,1-diphosphonate in calcium phosphate systems.蜜蜡酸盐和乙烷-1-羟基-1,1-二膦酸盐在磷酸钙体系中的体外和体内研究。
Calcif Tissue Res. 1977 May 31;23(1):53-60. doi: 10.1007/BF02012766.