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疟原虫裂殖子颈蛋白 2（PvRON2）的遗传序列特征和天然免疫反应

Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).

机构信息

Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, SP, Brazil.

Instituto Carlos Chagas, Fundação Oswaldo Cruz - FIOCRUZ, Curitiba, PR, Brazil.

出版信息

Malar J. 2018 Oct 31;17(1):401. doi: 10.1186/s12936-018-2543-7.

DOI:10.1186/s12936-018-2543-7
PMID:30382855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6208078/
Abstract

BACKGROUND: The genetic diversity of malaria antigens often results in allele variant-specific immunity, imposing a great challenge to vaccine development. Rhoptry Neck Protein 2 (PvRON2) is a blood-stage antigen that plays a key role during the erythrocyte invasion of Plasmodium vivax. This study investigates the genetic diversity of PvRON2 and the naturally acquired immune response to P. vivax isolates. RESULTS: Here, the genetic diversity of PvRON2 and the naturally acquired humoral immune response against PvRON2 in infected and non-infected individuals from a vivax malaria endemic area in Brazil was reported. The diversity analysis of PvRON2 revealed that the protein is conserved in isolates in Brazil and worldwide. A total of 18 (19%) patients had IgG antibodies to PvRON2. Additionally, the analysis of the antibody response in individuals who were not acutely infected with malaria, but had been infected with malaria in the past indicated that 32 patients (33%) exhibited an IgG immune response against PvRON2. CONCLUSIONS: PvRON2 was conserved among the studied isolates. The presence of naturally acquired antibodies to this protein in the absence of the disease suggests that PvRON2 induces a long-term antibody response. These results indicate that PvRON2 is a potential malaria vaccine candidate.

摘要

背景：疟原虫抗原的遗传多样性通常导致等位基因变异特异性免疫，这对疫苗的开发构成了巨大的挑战。裂殖体颈蛋白 2（PvRON2）是一种血期抗原，在间日疟原虫入侵红细胞的过程中起着关键作用。本研究调查了 PvRON2 的遗传多样性以及对间日疟原虫分离株的天然获得性免疫反应。

结果：本研究报道了巴西间日疟流行地区感染和未感染个体中 PvRON2 的遗传多样性和对 PvRON2 的天然体液免疫反应。PvRON2 的多样性分析表明，该蛋白在巴西和全球的分离株中是保守的。共有 18 名（19%）患者对 PvRON2 具有 IgG 抗体。此外，对过去曾感染过疟疾但目前未急性感染疟疾的个体的抗体反应分析表明，32 名患者（33%）对 PvRON2 表现出 IgG 免疫反应。

结论：在所研究的分离株中，PvRON2 是保守的。在没有疾病的情况下，这种蛋白存在天然获得的抗体，这表明 PvRON2 诱导了长期的抗体反应。这些结果表明 PvRON2 是一种潜在的疟疾疫苗候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/e7ae70d18cf8/12936_2018_2543_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/59ab0a781699/12936_2018_2543_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/9bef927b9753/12936_2018_2543_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/7ce44a72a5b5/12936_2018_2543_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/ff8f72ff4c01/12936_2018_2543_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/e7ae70d18cf8/12936_2018_2543_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/59ab0a781699/12936_2018_2543_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/9bef927b9753/12936_2018_2543_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/7ce44a72a5b5/12936_2018_2543_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/ff8f72ff4c01/12936_2018_2543_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccec/6208078/e7ae70d18cf8/12936_2018_2543_Fig5_HTML.jpg

相似文献

[1]
Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).

Malar J. 2018-10-31

[2]
The Antigenicity of Rhoptry Neck Protein 2 (RON2) B- and T-Epitopes Selected by HLA-DRB1 Binding Profile.

Front Cell Infect Microbiol. 2018-5-15

[3]
PvRON2, a new Plasmodium vivax rhoptry neck antigen.

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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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Int J Parasitol. 2005-2

[10]
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引用本文的文献

[1]
Development and longevity of naturally acquired antibody and memory B cell responses against Plasmodium vivax infection.

PLoS Negl Trop Dis. 2024-10

[2]
vaccine: What is the best way to go?

Front Immunol. 2022

[3]
Molecular Assessment of Domain I of Apical Membrane Antigen I Gene in : Implications in Invasion, Taxonomy, Vaccine Development, and Drug Discovery.

Can J Infect Dis Med Microbiol. 2022-10-7

[4]
Rosettes integrity protects Plasmodium vivax of being phagocytized.

Sci Rep. 2020-10-7

[5]
Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response.

PLoS Negl Trop Dis. 2020-7-8

[6]
RON2, a novel gene in contains conserved, immunodominant B-cell epitopes that induce antibodies that block merozoite invasion.

Parasitology. 2019-9-13

本文引用的文献

[1]
The Antigenicity of Rhoptry Neck Protein 2 (RON2) B- and T-Epitopes Selected by HLA-DRB1 Binding Profile.

Front Cell Infect Microbiol. 2018-5-15

[2]
Receptor-ligand and parasite protein-protein interactions in Plasmodium vivax: Analysing rhoptry neck proteins 2 and 4.

Cell Microbiol. 2018-3-26

[3]
Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana.

Parasit Vectors. 2017-8-23

[4]
Cross-reactivity between apical membrane antgen 1 and rhoptry neck protein 2 in P. vivax and P. falciparum: A structural and binding study.

PLoS One. 2017-8-17

[5]
A malaria vaccine protects monkeys against virulent infection.

NPJ Vaccines. 2017

[6]
Genetic diversity and antibody responses against Plasmodium falciparum vaccine candidate genes from Chhattisgarh, Central India: Implication for vaccine development.

PLoS One. 2017-8-7

[7]
Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination.

Malar J. 2017-7-4

[8]
Cell-Traversal Protein for Ookinetes and Sporozoites: Naturally Acquired Humoral Immune Response and B-Cell Epitope Mapping in Brazilian Amazon Inhabitants.

Front Immunol. 2017-2-7

[9]
Size polymorphism and low sequence diversity in the locus encoding the Plasmodium vivax rhoptry neck protein 4 (PvRON4) in Colombian isolates.

Malar J. 2016-10-18

[10]
The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria.

Sci Rep. 2016-9-8

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