Turnbull J
Can J Neurol Sci. 1987 May;14(2):122-6. doi: 10.1017/s0317167100026226.
There is much current interest in excitatory amino acids and their receptors because of their postulated involvement in several disorders of the nervous system. They function as neurotransmitters, but can act as neurotoxins in some situations. They have been implicated in the pathogenesis of cerebral hypoxic/ischemic and hypoglycemic damage, in epilepsy, in some degenerative diseases, and in some forms of neurotoxin-induced cerebral dysfunction. These diseases may reflect abnormality in a system which has evolved to provide synaptic plasticity essential for learning and memory. The purpose of this paper is to explore the ramifications of such a hypothesis.
由于推测兴奋性氨基酸及其受体参与了多种神经系统疾病，目前人们对它们极为关注。它们作为神经递质发挥作用，但在某些情况下可充当神经毒素。它们与脑缺氧/缺血性损伤、低血糖损伤、癫痫、某些退行性疾病以及某些形式的神经毒素诱导的脑功能障碍的发病机制有关。这些疾病可能反映了一个为学习和记忆提供必需的突触可塑性而进化的系统中的异常。本文的目的是探讨这一假说的影响。
