Departments of Bioengineering and Radiology, Stanford University, Stanford, CA, 94305, USA.
Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Med Phys. 2019 Jan;46(1):127-139. doi: 10.1002/mp.13272. Epub 2018 Nov 29.
A dynamic bowtie filter can modulate flux along both fan and view angles for reduced patient dose, scatter, and required photon flux, which is especially important for photon counting detectors (PCDs). Among the proposed dynamic bowtie designs, the piecewise-linear attenuator (Hsieh and Pelc, Med Phys. 2013;40:031910) offers more flexibility than conventional filters, but relies on analog positioning of a limited number of wedges. In this work, we study our previously proposed dynamic attenuator design, the fluid-filled dynamic bowtie filter (FDBF) that has digital control. Specifically, we use computer simulations to study fluence modulation, reconstructed image noise, and radiation dose and to compare it to other attenuators. FDBF is an array of small channels each of which, if it can be filled with dense fluid or emptied quickly, has a binary effect on the flux. The cumulative attenuation from each channel along the x-ray path contributes to the FDBF total attenuation.
An algorithm is proposed for selecting which FDBF channels should be filled. Two optimization metrics are considered: minimizing the maximum-count-rate for PCDs and minimizing peak-variance for energy-integrating detectors (EIDs) at fixed radiation dose (for optimizing dose efficiency). Using simulated chest, abdomen, and shoulder data, the performance is compared with a conventional bowtie and a piecewise-linear attenuator. For minimizing peak-variance, a perfect-attenuator (hypothetical filter capable of adjusting the fluence of each ray individually) and flat-variance attenuator are also included in the comparison. Two possible fluids, solutions of zinc bromide and gadolinium chloride, were tested.
To obtain the same SNR as routine clinical protocols, the proposed FDBF reduces the maximum-count-rate (across projection data, averaged over the test objects) of PCDs to 1.2 Mcps/mm , which is 55.8 and 3.3 times lower than the max-count-rate of the conventional bowtie and the piecewise-linear bowtie, respectively. (Averaged across objects for FDBF, the max-count-rate without object and FDBF is 2063.5 Mcps/mm , and the max-count-rate with object without FDBF is 749.8 Mcps/mm .) Moreover, for the peak-variance analysis, the FDBF can reduce entrance-energy-fluence (sum of energy incident on objects, used as a surrogate for dose) to 34% of the entrance-energy-fluence from the conventional filter on average while achieving the same peak noise level. Its entrance-energy-fluence reduction performance is only 7% worse than the perfect-attenuator on average and is 13% better than the piecewise-linear filter for chest and shoulder. Furthermore, the noise-map in reconstructed image domain from the FDBF is more uniform than the piecewise-linear filter, with 3 times less variation across the object. For the dose reduction task, the zinc bromide solution performed slightly poorer than stainless steel but was better than the gadolinium chloride solution.
The FDBF allows finer control over flux distribution compared to piecewise-linear and conventional bowtie filters. It can reduce the required maximum-count-rate for PCDs to a level achievable by current detector designs and offers a high dose reduction factor.
动态蝴蝶结滤波器可以调节扇区和视角的流量,以降低患者剂量、散射和所需的光子通量,这对于光子计数探测器(PCD)尤为重要。在所提出的动态蝴蝶结设计中,分段线性衰减器(Hsieh 和 Pelc,Med Phys. 2013;40:031910)比传统滤波器提供了更大的灵活性,但依赖于有限数量的楔形物的模拟定位。在这项工作中,我们研究了我们之前提出的动态衰减器设计,即具有数字控制的充液动态蝴蝶结滤波器(FDBF)。具体来说,我们使用计算机模拟来研究通量调制、重建图像噪声和辐射剂量,并将其与其他衰减器进行比较。FDBF 是一个由小通道组成的阵列,如果每个通道都可以充满密集的流体或快速排空,那么它对通量就会产生二进制影响。沿 X 射线路径的每个通道的累积衰减会导致 FDBF 总衰减。
提出了一种选择应填充哪些 FDBF 通道的算法。考虑了两种优化指标:最小化 PCD 的最大计数率和固定辐射剂量下能量积分探测器(EID)的峰值方差(用于优化剂量效率)。使用模拟的胸部、腹部和肩部数据,将性能与传统的蝴蝶结和分段线性衰减器进行比较。为了最小化峰值方差,还包括完美衰减器(能够单独调整每个射线的流量的假设滤波器)和平坦方差衰减器进行比较。测试了两种可能的流体,即溴化锌和氯化钆溶液。
为了获得与常规临床方案相同的信噪比,所提出的 FDBF 将 PCD 的最大计数率(在投影数据上,在测试对象上平均)降低到 1.2 Mcps/mm,分别比常规蝴蝶结和分段线性蝴蝶结的最大计数率低 55.8 倍和 3.3 倍。(在 FDBF 中,平均跨对象的最大计数率为 2063.5 Mcps/mm,没有对象和 FDBF 的最大计数率为 749.8 Mcps/mm。)此外,对于峰值方差分析,FDBF 可以将入口能量通量(入射到物体上的能量总和,用作剂量的替代物)降低到传统滤波器的平均入口能量通量的 34%,同时达到相同的峰值噪声水平。其入口能量通量减少性能平均比完美衰减器差 7%,比分段线性滤波器在胸部和肩部要好 13%。此外,FDBF 重建图像域中的噪声图比分段线性滤波器更均匀,在对象之间的变化小 3 倍。在剂量减少任务中,溴化锌溶液的性能略逊于不锈钢溶液,但优于氯化钆溶液。
FDBF 与分段线性和传统蝴蝶结滤波器相比,可以更精细地控制流量分布。它可以将 PCD 所需的最大计数率降低到当前探测器设计可以实现的水平,并提供高剂量减少因子。