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大麻急性效应与戒断症状调查:不同用户类型和年龄的差异反应

A Survey of Cannabis Acute Effects and Withdrawal Symptoms: Differential Responses Across User Types and Age.

作者信息

Sexton Michelle, Cuttler Carrie, Mischley Laurie K

机构信息

1 Department of Anesthesiology, University of California San Diego, San Diego, CA.

2 Department of Psychology, Washington State University, Pullman, WA.

出版信息

J Altern Complement Med. 2019 Mar;25(3):326-335. doi: 10.1089/acm.2018.0319. Epub 2018 Oct 31.

Abstract

OBJECTIVES

There is a rapidly evolving legal and medical culture around cannabis, with corresponding changes in the demographics of users. For instance, the percentage of the aging population accessing cannabis is growing substantially, outpacing other age groups. The goals of this study were to describe the acute effects of cannabis, subjective experiences of withdrawal, and beliefs around the addictiveness of cannabis, as well as to determine whether these effects differ as a function of age or reason for use (medical vs. recreational use). It was hypothesized that medical users and younger users would report fewer adverse effects.

SUBJECTS

Survey responses from 2905 cannabis users were analyzed.

RESULTS

Hierarchical logistic regression analyses were used to compare group percentages after statistically controlling for confounding differences in their demographic and cannabis use characteristics. The most commonly endorsed acute effects were improved sleep, more calm/peaceful, desire to eat, more creative, and dry mouth; while the most commonly endorsed withdrawal symptoms were irritability, insomnia, and anxiety. Relative to recreational users, medical users were less likely to report undesirable acute effects but were more likely to report undesirable withdrawal symptoms. Older (50+) individuals reported fewer undesirable acute effects and withdrawal symptoms compared with younger users (18-29). Only 17% of the total sample reported believing that cannabis is addictive, and this did not vary as a function of reason for use.

CONCLUSIONS

Older people and medical users appear to experience acute and withdrawal effects of cannabis differently than recreational and younger users, perhaps because these groups benefit more from the medicinal properties of cannabis. These data can provide descriptive information to help inform health care providers and potential consumers about effects of cannabis use.

摘要

目的

围绕大麻的法律和医学文化正在迅速演变,使用者的人口统计学特征也相应发生了变化。例如,使用大麻的老年人口比例正在大幅增长,超过了其他年龄组。本研究的目的是描述大麻的急性影响、戒断的主观体验以及对大麻成瘾性的看法,并确定这些影响是否因年龄或使用原因(医疗用途与娱乐用途)而异。研究假设是医疗使用者和年轻使用者报告的不良反应较少。

对象

分析了2905名大麻使用者的调查回复。

结果

采用分层逻辑回归分析,在对人口统计学和大麻使用特征的混杂差异进行统计学控制后,比较各组百分比。最常被认可的急性影响是睡眠改善、更加平静/安宁、食欲增加、更有创造力和口干;而最常被认可的戒断症状是易怒、失眠和焦虑。与娱乐使用者相比,医疗使用者报告不良急性影响的可能性较小,但报告不良戒断症状的可能性较大。与年轻使用者(18 - 29岁)相比,年龄较大(50岁以上)的个体报告的不良急性影响和戒断症状较少。在总样本中,只有17%的人认为大麻会上瘾,这并不因使用原因而异。

结论

老年人和医疗使用者似乎与娱乐使用者和年轻使用者在大麻的急性影响和戒断影响方面存在差异,可能是因为这些群体从大麻的药用特性中获益更多。这些数据可以提供描述性信息,以帮助医疗保健提供者和潜在消费者了解大麻使用的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/422b/6437627/6c941e5c4147/fig-1.jpg

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