Shionoiri H, Miyazaki N, Ochiai H, Ohta T, Asahina S, Tochikubo O, Kaneko Y
Clin Exp Hypertens A. 1987;9(2-3):599-603. doi: 10.3109/10641968709164230.
Intraarterial ambulatory pressure (AP) was recorded before and during therapy with captopril or enalapril in two groups with hypertension. Seven patients were admitted during the study. The monitoring of AP and heart rate (HR) was performed during placebo therapy and following a minimum period of 7 days of 25 mg twice daily captopril or 2.5 to 10 mg once daily enalapril. The AP and HR following percutaneous insertion of a cannula into the brachial artery were sampled then data were analyzed as reported previously. After the cannula was inserted, examinations of tilt-up, handgrip and ergometer were performed. Both drugs produced a significant reduction of ambulatory AP throughout 24 hours with preservation of the overall shape of the circadian curve. The results also demonstrated that both drugs had not affected normal daily activities. Thus, twice daily captopril and once daily enalapril can be used as the first-line therapy of hypertension.
在两组高血压患者中，记录了卡托普利或依那普利治疗前及治疗期间的动脉动态血压（AP）。研究期间收治了7例患者。在安慰剂治疗期间以及在每日两次服用25 mg卡托普利或每日一次服用2.5至10 mg依那普利至少7天后，进行了AP和心率（HR）监测。经皮将套管插入肱动脉后采集AP和HR数据，然后按先前报道的方法进行分析。插入套管后，进行了倾斜、握力和测力计检查。两种药物均使24小时动态AP显著降低，同时保留了昼夜曲线的整体形态。结果还表明，两种药物均未影响正常日常活动。因此，每日两次服用卡托普利和每日一次服用依那普利可作为高血压的一线治疗药物。
