Frewin D B, Ryan G J, Rennie G C
Department of Clinical Pharmacology, Royal Adelaide Hospital, S.A.
J Clin Pharmacol. 1991 Apr;31(4):327-32. doi: 10.1002/j.1552-4604.1991.tb03713.x.
Sixteen patients who had essential hypertension were stabilized on either captopril or enalapril monotherapy and had 24-hour blood pressure profiles monitored by using one of two automatic, non-invasive ambulatory systems: Spacelabs 5300 (Squibb, Princeton, NJ) or PAR Physioport II (Kardiotec, Mannheim). In four subjects (group 1), ambulatory pressures were repeated 4 to 6 weeks later using the same equipment and the same drug. In four subjects (group 2), the drug was changed (dose ratio: captopril:enalapril, 5:1) after the first measurement, but the monitoring equipment was not changed. In four subjects (group 3), the drug was constant, but the equipment was changed for the second measurement of ambulatory pressure. In four subjects (group 4), both drug and equipment were reversed after the first measurement. The results showed that both drugs (given once daily) controlled blood pressure during the 24-hour period, with no clinically significant difference between them.
16例原发性高血压患者接受卡托普利或依那普利单药治疗病情稳定，使用两种自动无创动态血压监测系统之一监测24小时血压：太空实验室5300（施贵宝公司，新泽西州普林斯顿）或PAR Physioport II（卡尔迪奥特克公司，曼海姆）。4名受试者（第1组）在4至6周后使用相同设备和相同药物重复进行动态血压测量。4名受试者（第2组）在首次测量后更换药物（剂量比：卡托普利：依那普利，5：1），但监测设备不变。4名受试者（第3组）药物不变，但更换设备进行第二次动态血压测量。4名受试者（第4组）在首次测量后同时更换药物和设备。结果显示，两种药物（每日给药1次）在24小时内均能控制血压，两者之间无临床显著差异。
