Xu Y H, Zhang S J, Wu C Q, Zhou J, Chang H F, Yu S Q
Environ Res. 1987 Aug;43(2):350-8. doi: 10.1016/s0013-9351(87)80035-x.
The pathogenicity of mixed dust from a fluorite mine was studied by animal experiments and in vitro tests. Animal experiments showed that calcium fluorite can induce only a foreign body reaction in the lungs; the fibrous nodular lesions induced by the fluorite mine dust are due mainly to its silica component. It was demonstrated that either silica or the mixed dust of a fluorite mine can stimulate pulmonary alveolar macrophages (PAMs) to release fibrogenetic factors in vitro, but calcium fluorite cannot. It was also demonstrated that having engulfed calcium fluorite, silica, or fluorite mine mixed dust, PAMs release an elastase-active substance. The authors suggest that the emphysematous lesion seen in autopsy material of pneumoconiosis of fluorite mine workers may be caused by calcium fluorite and silica.
通过动物实验和体外试验研究了萤石矿混合粉尘的致病性。动物实验表明，萤石只能在肺部诱发异物反应；萤石矿粉尘诱发的纤维结节性病变主要归因于其二氧化硅成分。结果表明，二氧化硅或萤石矿混合粉尘在体外均可刺激肺泡巨噬细胞（PAM）释放促纤维化因子，但萤石不能。还证明，吞噬了萤石、二氧化硅或萤石矿混合粉尘的PAM会释放一种具有弹性蛋白酶活性的物质。作者认为，萤石矿工人尘肺尸检材料中所见的肺气肿病变可能是由萤石和二氧化硅引起的。
