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两种不同的因子与多瘤病毒增强子的α结构域结合，其中一种因子还与SV40和c-fos增强子相互作用。

Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers.

作者信息

Piette J, Yaniv M

出版信息

EMBO J. 1987 May;6(5):1331-7. doi: 10.1002/j.1460-2075.1987.tb02372.x.

DOI:10.1002/j.1460-2075.1987.tb02372.x
PMID:3038517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC553937/
Abstract

Two nuclear factors from mouse 3T6 cells bind to a 22-bp segment constituting the alpha-domain of the polyoma virus enhancer. Binding of each factor can be competed out selectively by the appropriate double-stranded oligonucleotide, indicating that this binding is not strictly cooperative. Sequence homology between the two binding sites and the similar size of the protected regions may indicate that both factors, PEA1 and PEA2, are closely related. The binding site of PEA1 is centered on a sequence showing strong homology to the SV40 enhancer, the binding site of PEA2 is located immediately adjacent to it and shows a strong homology to the c-fos enhancer. Surprisingly, both SV40 and c-fos enhancers interact with PEA1, probably due to the presence of an extra base pair relative to c-fos in the PEA2 site. Factor PEA1 is probably identical to the recently described activator protein 1 (AP1).

摘要

来自小鼠3T6细胞的两种核因子与构成多瘤病毒增强子α结构域的一个22碱基对片段结合。每种因子的结合都可被相应的双链寡核苷酸选择性地竞争掉，这表明这种结合并非严格协同的。两个结合位点之间的序列同源性以及受保护区域的相似大小可能表明，这两种因子PEA1和PEA2密切相关。PEA1的结合位点以与SV40增强子具有高度同源性的序列为中心，PEA2的结合位点紧邻其定位，并与c-fos增强子具有高度同源性。令人惊讶的是，SV40和c-fos增强子都与PEA1相互作用，这可能是由于PEA2位点相对于c-fos存在一个额外的碱基对。因子PEA1可能与最近描述的激活蛋白1（AP1）相同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/6dedc0909970/emboj00245-0188-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/389693b6f984/emboj00245-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/e8baaa71c983/emboj00245-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/2ddd4c9ce27a/emboj00245-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/4cd223c50e4f/emboj00245-0187-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/ececd71ffc69/emboj00245-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/6dedc0909970/emboj00245-0188-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/389693b6f984/emboj00245-0185-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/e8baaa71c983/emboj00245-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/2ddd4c9ce27a/emboj00245-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/4cd223c50e4f/emboj00245-0187-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/ececd71ffc69/emboj00245-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b6/553937/6dedc0909970/emboj00245-0188-b.jpg

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