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多瘤病毒DNA复制的宿主物种特异性不会因猴病毒40的72碱基对重复序列而改变。

Host species specificity of polyomavirus DNA replication is not altered by simian virus 40 72-base-pair repeats.

作者信息

Campbell B A, Villarreal L P

出版信息

Mol Cell Biol. 1985 Jun;5(6):1534-7. doi: 10.1128/mcb.5.6.1534-1537.1985.

DOI:10.1128/mcb.5.6.1534-1537.1985
PMID:2993870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC366888/
Abstract

The simian virus 40 72-base-pair repeats substituted for the polyomavirus enhancer, allowing replication and transcription in mouse 3T6 but not monkey CV-1 cells. A polyomavirus genome containing the entire simian virus 40 control region replicated at low levels in 3T6 and CV-1 cells; however, transcripts were detected only in 3T6 cells. Our results suggest that the simian virus 40 72-base-pair repeats are unable to alter the host species specificity of the complete polyomavirus genome.

摘要

用猿猴病毒40的72碱基对重复序列替换多瘤病毒增强子，可使其在小鼠3T6细胞而非猴CV-1细胞中进行复制和转录。含有整个猿猴病毒40控制区的多瘤病毒基因组在3T6和CV-1细胞中低水平复制；然而，仅在3T6细胞中检测到转录本。我们的结果表明，猿猴病毒40的72碱基对重复序列无法改变完整多瘤病毒基因组的宿主物种特异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c9/366888/b192963f167f/molcellb00102-0348-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c9/366888/383484f77684/molcellb00102-0347-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c9/366888/b192963f167f/molcellb00102-0348-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c9/366888/383484f77684/molcellb00102-0347-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c9/366888/b192963f167f/molcellb00102-0348-a.jpg

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本文引用的文献

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An SV40 "enhancer trap" incorporates exogenous enhancers or generates enhancers from its own sequences.一个SV40“增强子陷阱”包含外源性增强子或从其自身序列产生增强子。
Cell. 1984 Apr;36(4):983-92. doi: 10.1016/0092-8674(84)90048-5.
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DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells.来自F9 PyEC突变体的DNA片段可增加转染的F9细胞中异源基因的表达。
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Lymphoid and other tissue-specific phenotypes of polyomavirus enhancer recombinants: positive and negative combinational effects on enhancer specificity and activity.多瘤病毒增强子重组体的淋巴样及其他组织特异性表型：对增强子特异性和活性的正负组合效应
Mol Cell Biol. 1986 Jun;6(6):2068-79. doi: 10.1128/mcb.6.6.2068-2079.1986.
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Construction and characterization of hybrid polyomavirus genomes.杂交多瘤病毒基因组的构建与特性分析
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Sequence-dependent DNA replication in preimplantation mouse embryos.植入前小鼠胚胎中依赖序列的DNA复制。
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Tissue specific phenotypes of polyomavirus A and B enhancer transpositions and duplications: positional and nonpositional effects on replication in lymphoid cells.多瘤病毒A和B增强子转位与重复的组织特异性表型：对淋巴细胞复制的位置效应和非位置效应
Virus Genes. 1987 Nov;1(1):23-34. doi: 10.1007/BF00125683.
9
Constitutive expression of simian virus 40 large T antigen in monkey cells activates their capacity to support polyomavirus replication.猴病毒40大T抗原在猴细胞中的组成型表达激活了它们支持多瘤病毒复制的能力。
J Virol. 1989 Dec;63(12):5478-82. doi: 10.1128/JVI.63.12.5478-5482.1989.
10
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J Virol. 1989 Dec;63(12):5371-85. doi: 10.1128/JVI.63.12.5371-5385.1989.
通过Elutip-d亲和层析从低熔点琼脂糖中定量分离DNA限制片段
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Mol Cell Biol. 1983 Aug;3(8):1381-8. doi: 10.1128/mcb.3.8.1381-1388.1983.
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High efficiency polyoma DNA transfection of chloroquine treated cells.氯喹处理细胞的高效多瘤病毒DNA转染
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Transcriptional 'enhancers' from SV40 and polyoma virus show a cell type preference.来自猴病毒40（SV40）和多瘤病毒的转录“增强子”表现出细胞类型偏好性。
Nucleic Acids Res. 1982 Dec 20;10(24):7965-76. doi: 10.1093/nar/10.24.7965.
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The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements.SV40 72碱基对重复序列优先增强从近端天然或替代启动子元件起始的转录。
Cell. 1983 Feb;32(2):503-14. doi: 10.1016/0092-8674(83)90470-1.
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Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.来自猴病毒40和莫洛尼氏鼠肉瘤病毒的串联重复序列对转录的宿主特异性激活。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6453-7. doi: 10.1073/pnas.79.21.6453.