AP1通过促进T抗原介导的DNA解旋来增强多瘤病毒DNA复制。
AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNA.
作者信息
Guo W, Tang W J, Bu X, Bermudez V, Martin M, Folk W R
机构信息
Department of Biochemistry, University of Missouri--Columbia 65202, USA.
出版信息
J Virol. 1996 Aug;70(8):4914-8. doi: 10.1128/JVI.70.8.4914-4918.1996.
Abstract
An early step in the initiation of polyomavirus DNA replication is viral large-T-antigen-mediated unwinding of the origin. We report that components of the AP1 transcription factor, Fos and Jun, interact with T antigen in vitro to enhance unwinding of the viral origin. This provides a biochemical basis for the capacity of AP1 to activate viral DNA replication in vivo.
摘要
多瘤病毒DNA复制起始的早期步骤是病毒大T抗原介导的起始点解旋。我们报道，AP1转录因子的组成成分Fos和Jun在体外与T抗原相互作用，以增强病毒起始点的解旋。这为AP1在体内激活病毒DNA复制的能力提供了生化基础。
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