Matsui K, Mukoyama M, Adachi K, Ando K
Jikken Dobutsu. 1987 Apr;36(2):185-9. doi: 10.1538/expanim1978.36.2_185.
Wriggle mouse Sagami (WMS), a newly discovered BALB/C mouse strain, is characterized by its locomotor instability, abnormal gait pattern and neck wriggling. Although the growth of WMS mice is delayed, compared with normal BALB/C mice, the brain size corresponds to the relatively smaller body weight. In gross or histological examinations no local atrophy appears in the cerebrum, cerebellum, brain stem or spinal cord. The c-GMP level in the WMS cerebellum is decreased, but the c-AMP level is normal. The ataxic gait is not improved significantly by the administration of thyrotropin releasing hormone (TRH). These results indicate that the mechanism inducing ataxia and abnormal gait pattern in WMS may be different from those in other genetically-determined ataxic mice, e. g., Rolling mouse Nagaya (RMN), PCD, Staggerer and Reeler.
扭动小鼠相模（WMS）是一种新发现的BALB/C小鼠品系，其特征为运动不稳定、步态异常和颈部扭动。尽管WMS小鼠的生长发育延迟，但与正常BALB/C小鼠相比，其脑大小与相对较小的体重相符。在大体或组织学检查中，大脑、小脑、脑干或脊髓均未出现局部萎缩。WMS小鼠小脑中的环磷酸鸟苷（c-GMP）水平降低，但环磷酸腺苷（c-AMP）水平正常。给予促甲状腺激素释放激素（TRH）后，共济失调步态并未得到明显改善。这些结果表明，WMS小鼠中诱导共济失调和异常步态模式的机制可能与其他基因决定的共济失调小鼠，如滚动小鼠长谷（RMN）、PCD、蹒跚者和旋转者不同。
