Matsui K, Kato N, Ando K
National Institute of Neuroscience, N. C. N. P., Tokyo, Japan.
Jikken Dobutsu. 1988 Jan;37(1):1-6. doi: 10.1538/expanim1978.37.1_1.
Spontaneous movement and ataxic gait in ataxic mice showing various pathological changes in the cerebellum were investigated according to developmental stage by the open-field method of comparison with normal mice. As the cerebellum contains relatively high levels of cyclic nucleotide, its concentrations was measured by radioimmunoassay to elucidate the correlation between spontaneous movement and ataxic gait and the neurological changes. The movements of Rolling Mouse Nagoya (RMN), Weaver and Reeler mice without Purkinje Cell Degeneration (PCD) were found to decrease at 4 and 12 weeks of age. The degree of ataxic gait worsen in RMN, was unchanged in Reeler and improved in Weaver and PCD mice. The cerebellar c-GMP concentration of ataxic mice was decreased, while no significant changes in c-AMP concentration were found in comparison with normal mice. With development, the level of cerebellar c-GMP in Weaver mice increased, but this was not apparent in RMN, Reeler or PCD mice. The results of this investigation indicated that there may be some relation between the degree of ataxic gait and the level of cerebellar c-GMP in Weaver mice.
通过与正常小鼠对比的旷场试验方法，根据发育阶段对小脑呈现各种病理变化的共济失调小鼠的自发运动和共济失调步态进行了研究。由于小脑含有相对较高水平的环核苷酸，通过放射免疫测定法测量其浓度，以阐明自发运动、共济失调步态与神经学变化之间的相关性。发现名古屋滚动小鼠（RMN）、韦弗小鼠和无浦肯野细胞变性（PCD）的里尔小鼠在4周和12周龄时运动减少。RMN小鼠的共济失调步态程度加重，里尔小鼠不变，韦弗小鼠和PCD小鼠有所改善。与正常小鼠相比，共济失调小鼠的小脑c-GMP浓度降低，而c-AMP浓度未发现显著变化。随着发育，韦弗小鼠小脑c-GMP水平升高，但在RMN、里尔或PCD小鼠中不明显。本研究结果表明，韦弗小鼠的共济失调步态程度与小脑c-GMP水平之间可能存在某种关系。
