Mano Y, Matsui K, Toyoshima E, Ando K
Acta Neurol Scand. 1986 Apr;73(4):352-8. doi: 10.1111/j.1600-0404.1986.tb03289.x.
The Rolling mouse Nagoya (RMN), Staggerer, Weaver and Reeler, all of which show hereditary ataxia, were intraperitoneally injected with 25 mg/kg of thyrotropin-releasing hormone (TRH-T) or physiological saline, and changes in the motions of these animals were observed by an Animex II and an open field method. All four strains of mice with ataxia showed improvement of ataxia and an increase in the motion volume, but these changes were not necessarily consistent in degree. Improvement of ataxia was most marked in the RMN and the Staggerer, moderate in the Weaver and slight in the Reeler, which showed enhanced tremor. The relationship between the competence of transmitting information in the cerebellum and improvement of ataxia by the injection of TRH-T aroused our interest.
滚动小鼠名古屋品系（RMN）、蹒跚小鼠、摇摆小鼠和旋转小鼠均表现出遗传性共济失调，给它们腹腔注射25mg/kg促甲状腺激素释放激素（TRH-T）或生理盐水，并用Animex II和旷场法观察这些动物的运动变化。所有四株共济失调小鼠均表现出共济失调改善和运动量增加，但这些变化在程度上不一定一致。RMN和蹒跚小鼠的共济失调改善最为明显，摇摆小鼠为中度，旋转小鼠为轻度，旋转小鼠表现出震颤增强。小脑传递信息的能力与注射TRH-T改善共济失调之间的关系引起了我们的兴趣。
