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Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.多祖先队列的全基因组分析确定了影响眼压和青光眼易感性的新基因座。
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线性回归中贝叶斯因子的零分布

On the Null Distribution of Bayes Factors in Linear Regression.

作者信息

Zhou Quan, Guan Yongtao

机构信息

Baylor College of Medicine.

出版信息

J Am Stat Assoc. 2018;113(523):1362-1371. doi: 10.1080/01621459.2017.1328361. Epub 2018 Jun 8.

DOI:10.1080/01621459.2017.1328361
PMID:30386004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6205752/
Abstract

We show that under the null, the 2 log(Bayes factor) is asymptotically distributed as a weighted sum of chi-squared random variables with a shifted mean. This claim holds for Bayesian multi-linear regression with a family of conjugate priors, namely, the normal-inverse-gamma prior, the g-prior, and the normal prior. Our results have three immediate impacts. First, we can compute analytically a p-value associated with a Bayes factor without the need of permutation. We provide a software package that can evaluate the p-value associated with Bayes factor efficiently and accurately. Second, the null distribution is illuminating to some intrinsic properties of Bayes factor, namely, how Bayes factor quantitatively depends on prior and the genesis of Bartlett's paradox. Third, enlightened by the null distribution of Bayes factor, we formulate a novel scaled Bayes factor that depends less on the prior and is immune to Bartlett's paradox. When two tests have an identical p-value, the test with a larger power tends to have a larger scaled Bayes factor, a desirable property that is missing for the (unscaled) Bayes factor.

摘要

我们证明,在原假设下,2倍对数贝叶斯因子渐近地服从均值有偏移的卡方随机变量加权和的分布。这一结论适用于具有共轭先验族的贝叶斯多元线性回归,即正态-逆伽马先验、g先验和正态先验。我们的结果有三个直接影响。首先,我们可以解析地计算与贝叶斯因子相关的p值,而无需进行排列检验。我们提供了一个软件包,它可以高效且准确地评估与贝叶斯因子相关的p值。其次,原假设分布揭示了贝叶斯因子的一些内在属性,即贝叶斯因子如何定量地依赖于先验以及巴特利特悖论的成因。第三,受贝叶斯因子原假设分布的启发,我们提出了一种新颖的缩放贝叶斯因子,它对先验的依赖较小,并且不受巴特利特悖论的影响。当两个检验具有相同的p值时,功效较大的检验往往具有较大的缩放贝叶斯因子,这是(未缩放的)贝叶斯因子所缺乏的理想属性。