Department of Farm Resources and Production Medicine, Faculty of Veterinary Medicine, Kasetsart University, Nakhon Pathom, Thailand.
Faculty of Veterinary Medicine, Kamphaeng Saen Veterinary Diagnostic Center (KVDC), Kasetsart University, Nakhon Pathom, Thailand.
Transbound Emerg Dis. 2019 Jan;66(1):611-616. doi: 10.1111/tbed.13057. Epub 2018 Nov 23.
Porcine circovirus type 3 (PCV3) has recently been detected in pigs worldwide, with similar clinical manifestations to porcine circovirus-associated disease (PCVAD) from porcine circovirus type 2 (PCV2) infection. Here, we report the identification and molecular epidemiology of PCV3 in swine in Thailand from clinical samples retrieved from 2006 to 2017. The epidemiological data revealed co-infection with PCV2, PRRSV, and PCV2/PRRSV was common in our samples. Circulating PCV3 from this study shared a high similarity of nucleotide and deduced amino acid sequences of the partial capsid gene (96.7%-100% and 96.7%-100% respectively), indicated the genetic stability of PCV3 in Thailand. Phylogenetic analysis based on the capsid gene revealed scatter clustering with current PCV3 having no relation to the geographical origin of the virus strains. In this retrospective study, results have demonstrated that PCV3 has spread extensively within Thai swine from as early as 2006 and may also be involved in PRDC and PCVAD.
猪圆环病毒 3 型（PCV3）最近在全球范围内的猪群中被检测到，其临床表现与由猪圆环病毒 2 型（PCV2）感染引起的猪圆环病毒相关疾病（PCVAD）相似。在这里，我们报告了从 2006 年至 2017 年从临床样本中采集的泰国猪中 PCV3 的鉴定和分子流行病学。流行病学数据显示，PCV2、PRRSV 和 PCV2/PRRSV 的合并感染在我们的样本中很常见。本研究中循环的 PCV3 的部分衣壳基因的核苷酸和推导的氨基酸序列具有很高的相似性（分别为 96.7%-100%和 96.7%-100%），表明 PCV3 在泰国具有遗传稳定性。基于衣壳基因的系统进化分析显示，散在聚类与当前 PCV3 与病毒株的地理起源无关。在这项回顾性研究中，结果表明，PCV3 早在 2006 年就在泰国猪群中广泛传播，也可能与 PRDC 和 PCVAD 有关。
