Department of Ophthalmology & Visual Science, Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200031, China.
Key NHC Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, 200031, China.
Adv Healthc Mater. 2018 Dec;7(23):e1801047. doi: 10.1002/adhm.201801047. Epub 2018 Nov 2.
Nitric oxide (NO) donors are ideal drug candidates for reducing intraocular pressure in the treatment of glaucoma. However, poor cornea penetration, short duration of efficacy, and narrow therapeutic index of most NO donors obstruct their clinical applications in glaucoma treatment. This study reports a novel NO donor delivery system based on mesoporous silica nanoparticles that can readily overcome the above difficulties and deliver the NO-donating drug sodium nitroprusside to the target tissues (trabecular meshwork and Schlemm's canal). Mesoporous silica nanoparticles loaded with sodium nitroprusside can produce more exogenous NO and sustain higher NO concentration in animal eye models, which significantly extend the duration of intraocular pressure reduction from 3 to 48 h with only 1/40 of the dose of sodium nitroprusside solution. These findings open up the possibility of mesoporous silica nanoparticles loading sodium nitroprusside for effective management of ocular hypertension.
一氧化氮（NO）供体是降低青光眼眼内压的理想候选药物。然而，大多数 NO 供体的角膜穿透性差、疗效持续时间短和治疗指数窄，阻碍了它们在青光眼治疗中的临床应用。本研究报告了一种基于介孔硅纳米粒子的新型 NO 供体传递系统，它可以轻易克服上述困难，将 NO 供体药物硝普钠递送到靶组织（小梁网和施莱姆氏管）。负载硝普钠的介孔硅纳米粒子可以产生更多的外源性 NO，并在动物眼模型中维持更高的 NO 浓度，从而将眼压降低的持续时间从 3 小时延长至 48 小时，所需硝普钠溶液的剂量仅为 1/40。这些发现为介孔硅纳米粒子负载硝普钠有效治疗眼高压开辟了可能性。
