School of Medicine, Nankai University, Tianjin, People's Republic of China.
Senior Department of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China.
Int J Nanomedicine. 2024 May 6;19:4021-4040. doi: 10.2147/IJN.S463679. eCollection 2024.
Cataract is a leading cause of blindness globally, and its surgical treatment poses a significant burden on global healthcare. Pharmacologic therapies, including antioxidants and protein aggregation reversal agents, have attracted great attention in the treatment of cataracts in recent years. Due to the anatomical and physiological barriers of the eye, the effectiveness of traditional eye drops for delivering drugs topically to the lens is hindered. The advancements in nanomedicine present novel and promising strategies for addressing challenges in drug delivery to the lens, including the development of nanoparticle formulations that can improve drug penetration into the anterior segment and enable sustained release of medications. This review introduces various cutting-edge drug delivery systems for cataract treatment, highlighting their physicochemical properties and surface engineering for optimal design, thus providing impetus for further innovative research and potential clinical applications of anti-cataract drugs.
白内障是全球致盲的主要原因，其手术治疗给全球医疗保健带来了巨大负担。近年来，药理学治疗方法，包括抗氧化剂和蛋白聚集逆转剂，在白内障的治疗中引起了广泛关注。由于眼睛的解剖和生理屏障，传统眼药水将药物局部递送到晶状体的效果受到阻碍。纳米医学的进步为解决药物递送到晶状体的挑战提供了新颖而有前途的策略，包括开发纳米颗粒制剂，以改善药物穿透前节并实现药物的持续释放。本综述介绍了各种用于白内障治疗的先进药物递送系统，强调了其物理化学性质和表面工程，以实现最佳设计，从而为抗白内障药物的进一步创新研究和潜在临床应用提供了动力。
