Wang Juan, Li Boxuan, Kompella Uday B, Yang Hu
College of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, China.
Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
MedComm Biomater Appl. 2023 Mar;2(1). doi: 10.1002/mba2.30. Epub 2023 Feb 20.
Due to high structural flexibility, multidrug carrying capability, and tunable size, dendrimers have been used as suitable carriers for ophthalmic drug delivery. Drug molecules can be either encapsulated or chemically coupled to dendrimers. The nanoscopic size, spheroidal shape, and cationic surface of polyamidoamine (PAMAM) dendrimers promote their interaction with the cornea and result in prolonged precorneal retention. Dendrimers could be further cross-linked to produce three-dimensional hydrogel networks or dendrimer hydrogels (DH). The properties of the DH can be readily adjusted to maintain both fluidity and adhesiveness, making them suitable for developing topical ocular drug formulations. Micro-/nano-sized DHs, that is, dendrimer micro-/nano-gels, have unique properties such as ease of administration, large specific surface area for adhesion, and drug targeting functionalities, making them attractive for ophthalmic drug delivery. This perspective reports advances in PAMAM dendrimer based drug delivery systems including drug conjugates and micro- and nano-gels to enhance and sustain the delivery of multiple anti-glaucoma drugs, Dendrimer and dendrimer gel-derived drug delivery systems hold great potential as multifunctional topical drug delivery systems for the eye.
由于具有高度的结构灵活性、多药携带能力和可调节的尺寸，树枝状大分子已被用作眼科药物递送的合适载体。药物分子可以被封装在树枝状大分子中，也可以与树枝状大分子化学偶联。聚酰胺胺（PAMAM）树枝状大分子的纳米尺寸、球形形状和阳离子表面促进了它们与角膜的相互作用，并导致角膜前滞留时间延长。树枝状大分子可以进一步交联以产生三维水凝胶网络或树枝状水凝胶（DH）。DH的性质可以很容易地调节以保持流动性和粘附性，使其适合于开发局部眼部药物制剂。微/纳米尺寸的DH，即树枝状微/纳米凝胶，具有易于给药、大的粘附比表面积和药物靶向功能等独特性质，使其对眼科药物递送具有吸引力。这篇综述报道了基于PAMAM树枝状大分子的药物递送系统的进展，包括药物缀合物以及微凝胶和纳米凝胶，以增强和维持多种抗青光眼药物的递送。树枝状大分子和树枝状凝胶衍生的药物递送系统作为多功能眼部局部药物递送系统具有巨大潜力。
