Section of Gastroenterology, Boston University Medical Center, Boston, Massachusetts, USA.
Inflamm Bowel Dis. 2019 Apr 11;25(5):843-852. doi: 10.1093/ibd/izy334.
Sleep deprivation and lack of sleep are a significant public health concern. Several studies have suggested an intricate relationship between sleep, inflammation, and the immune system. Poor sleep has been described well in subjects with inflammatory bowel disease (IBD) and has been linked to disease activity and shown as a predictor for subclinical inflammation and a risk factor for relapse and poorer outcomes. This review describes the relationship between poor sleep, inflammation, and the immune system. Furthermore, the relationship between sleep and IBD are reviewed. The causes of poor sleep in inflammatory bowel disease patient is discussed. Potential therapeutic interventions for the management of common sleep disturbances are provided.
睡眠剥夺和睡眠不足是一个重大的公共卫生关注点。多项研究表明，睡眠、炎症和免疫系统之间存在复杂的关系。炎症性肠病（IBD）患者的睡眠质量较差已得到充分描述，并且与疾病活动有关，被认为是亚临床炎症的预测因素，也是复发和预后较差的危险因素。本综述描述了睡眠质量差、炎症和免疫系统之间的关系。此外，还回顾了睡眠与 IBD 之间的关系。讨论了炎症性肠病患者睡眠质量差的原因。提供了管理常见睡眠障碍的潜在治疗干预措施。
