Zhang Qu, Yi Jing, Wu Yemei
Department of Radiotherapy Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Nutr. 2024 Oct 18;11:1469779. doi: 10.3389/fnut.2024.1469779. eCollection 2024.
The association between oxidative stress, as measured by the Oxidative Balance Score (OBS), and sleep quality remains unclear. The primary objective of this investigation was to clarify this relationship and to explore the potential involvement of oxidative stress and inflammation.
Data from 15,198 participants in the National Health and Nutrition Examination Survey 2007-2014 were analyzed. Sleep quality indicators, including sleep disorder, trouble, and duration, were assessed. The OBS, comprising information on 16 dietary nutrients and 4 lifestyle factors, was then calculated. Multivariable logistic and linear regression models were employed to investigate the correlation between OBS and sleep quality. Additionally, mediation analyses were conducted to evaluate the potential effects of oxidative stress and inflammation.
We demonstrated a correlation between an elevated OBS and reduced sleep disorders (OR, 0.72; 95% CI, 0.58-0.91; = 0.0055), reduced sleep trouble (OR, 0.81; 95% CI, 0.69-0.96; = 0.0174), and prolonged sleep duration ( 0.009; 95% CI, 0.0002-0.0160; = 0.015) when comparing the highest and lowest tertiles. Dietary factors exhibited autonomous correlations with sleep duration, whereas lifestyle factors displayed independent associations with sleep trouble and sleep disorders. Moreover, the relationships between OBS and both sleep disorders and trouble were influenced by albumin, -glutamyl transferase, total bilirubin, and white blood cells, with combined mediation effects of 34.66 and 29.54%, respectively (both < 0.001). Sensitivity analyses revealed a significant association between OBS and sleep disorder ( < 0.001).
This study revealed a positive correlation between an elevated OBS and improved sleep quality, manifested by decreased sleep disorders, mitigated sleep trouble, and prolonged sleep duration. This is potentially mediated by oxidative stress and inflammation. Therefore, the study underscores the importance of adopting a diet rich in antioxidants and healthy lifestyle choices to address sleep-related concerns, providing a novel avenue for enhancing overall sleep quality.
通过氧化平衡评分（OBS）衡量的氧化应激与睡眠质量之间的关联尚不清楚。本研究的主要目的是阐明这种关系，并探讨氧化应激和炎症的潜在作用。
分析了2007 - 2014年美国国家健康与营养检查调查中15198名参与者的数据。评估了睡眠质量指标，包括睡眠障碍、睡眠问题和睡眠时间。然后计算包含16种膳食营养素和4种生活方式因素信息的OBS。采用多变量逻辑回归和线性回归模型研究OBS与睡眠质量之间的相关性。此外，进行中介分析以评估氧化应激和炎症的潜在影响。
我们发现，与最高和最低三分位数相比，OBS升高与睡眠障碍减少（OR，0.72；95%CI，0.58 - 0.91；P = 0.0055）、睡眠问题减少（OR，0.81；95%CI，0.69 - 0.96；P = 0.0174）以及睡眠时间延长（β = 0.009；95%CI，0.0002 - 0.0160；P = 0.015）相关。膳食因素与睡眠时间呈现独立相关性，而生活方式因素与睡眠问题和睡眠障碍存在独立关联。此外，OBS与睡眠障碍和睡眠问题之间的关系受白蛋白、γ-谷氨酰转移酶、总胆红素和白细胞影响，联合中介效应分别为34.66%和29.54%（均P < 0.001）。敏感性分析显示OBS与睡眠障碍之间存在显著关联（P < 0.001）。
本研究揭示OBS升高与睡眠质量改善呈正相关，表现为睡眠障碍减少、睡眠问题减轻和睡眠时间延长。这可能由氧化应激和炎症介导。因此，该研究强调了采用富含抗氧化剂的饮食和健康生活方式选择来解决睡眠相关问题的重要性，为提高整体睡眠质量提供了新途径。
