亚精胺对痴呆风险老年人记忆表现的影响：一项随机对照试验。

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.

机构信息

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, NeuroCure Cluster of Excellence, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Center for Stroke Research, Berlin, Germany.

出版信息

Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4.

DOI:10.1016/j.cortex.2018.09.014

PMID:30388439

Abstract

INTRODUCTION

Nutritional intervention with the natural polyamine spermidine, an autophagy-enhancing agent, can prevent memory loss in aging model organisms. This is the first human study to evaluate the impact of spermidine supplementation on memory performance in older adults at risk for the development of Alzheimer's disease.

METHODS

Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement. Effects of intervention were assessed using the behavioral mnemonic similarity task, measured at baseline and post-intervention visits. Data analysis was focused on reporting and interpreting effectiveness based on effect sizes.

RESULTS

Memory performance was moderately enhanced in the spermidine group compared with placebo at the end of intervention [contrast mean = .17, 95% confidence interval (CI): -.01, .35, Cohen's d = .77, 95% CI: 0, 1.53]. Mnemonic discrimination ability improved in the spermidine-treated group with a medium effect size (mean difference = -.11, 95% CI: -.19, -.03, Cohen's d = .79, 95% CI: .01, 1.55). A similar effect was not found in the placebo-treated group (mean difference = .07, 95% CI: -.13, .27, Cohen's d = -.20, 95% CI: -.94, .54).

DISCUSSION

In this pilot trial, nutritional spermidine was associated with a positive impact on memory performance in older adults with subject cognitive decline. The beneficial effect might be mediated by stimulation of neuromodulatory actions in the memory system. A follow-up Phase IIb randomized controlled trial will help validate the therapeutic potential of spermidine supplementation and delineate possible neurophysiological mechanisms of action.

TRIAL REGISTRATION

Registered in ClinicalTrials.gov with the Identifier NCT02755246.

摘要

简介

营养干预剂天然多胺亚精胺是一种自噬增强剂，可预防衰老模型生物的记忆丧失。这是第一项评估补充亚精胺对有发生阿尔茨海默病风险的老年成年人记忆表现影响的人体研究。

方法

本研究纳入了 30 名认知正常但有主观认知下降的参与者（年龄 60-80 岁），进行了为期三个月的随机、安慰剂对照、双盲 IIa 期试验，给予富含亚精胺的植物提取物补充剂。使用行为记忆相似性任务在基线和干预后访视时评估干预的效果。数据分析集中于基于效应量报告和解释效果。

结果

与安慰剂组相比，干预结束时亚精胺组的记忆表现有适度提高[对比均值=0.17，95%置信区间（CI）：-.01，.35，Cohen's d=0.77，95% CI：0，1.53]。在亚精胺治疗组中，记忆辨别能力提高，具有中等效应量（平均差值=-.11，95% CI：-.19，-.03，Cohen's d=0.79，95% CI：.01，1.55）。在安慰剂治疗组中未发现类似的效果（平均差值=0.07，95% CI：-.13，.27，Cohen's d=-.20，95% CI：-.94，.54）。