组织单元化：肺细胞协同作用驱动肺泡巨噬细胞发育。
Tissue Unit-ed: Lung Cells Team up to Drive Alveolar Macrophage Development.
机构信息
Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Centre for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB-UGent Centre for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
出版信息
Cell. 2018 Nov 1;175(4):898-900. doi: 10.1016/j.cell.2018.10.031.
Using single-cell RNA sequencing of both immune and non-immune cells in the developing lung, Cohen et al. map candidate cell-cell interactions during alveolar macrophage development. This revealed potential cross-talk between epithelial cells, ILC2s, basophils, and the developing macrophages, which were validated both in vitro and in vivo.
使用单细胞 RNA 测序技术对发育中的肺部的免疫细胞和非免疫细胞进行分析，Cohen 等人绘制了肺泡巨噬细胞发育过程中候选细胞-细胞相互作用的图谱。这揭示了上皮细胞、ILC2、嗜碱性粒细胞和发育中的巨噬细胞之间的潜在串扰，这些在体外和体内都得到了验证。
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