甲氧苄啶/磺胺甲恶唑对流感嗜血杆菌的定量抑制作用。
Quantitative inhibition of Haemophilus influenzae by trimethoprim/sulfamethoxazole.
作者信息
Pelton S I, Shurin P A, Klein J O, Finland M
出版信息
Antimicrob Agents Chemother. 1977 Dec;12(6):649-54. doi: 10.1128/AAC.12.6.649.
Abstract
We evaluated the inhibitory effect of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination, against 34 strains of Haemophilus influenzae. Growth inhibition was determined after incubation for 18 h by comparing viable counts of cultures in drug-containing medium with corresponding counts of control cultures in drug-free medium. In a modified, thymidine-deficient Levinthal broth, the numbers of colony-forming units of all the isolates tested were reduced 100-fold or more by TMP/SMZ (1.25/25 mug/ml) as compared with growth without drug. Inhibition was significantly greater with TMP/SMZ than with either TMP or SMZ alone. Ampicillin-susceptible and ampicillin-resistant strains were equally susceptible to TMP/SMZ. Growth of nontypable strains was inhibited more than growth of type b organisms.
摘要
我们评估了甲氧苄啶（TMP）和磺胺甲恶唑（SMZ）单独及联合使用对34株流感嗜血杆菌的抑制作用。通过比较含药培养基中培养物的活菌计数与无药培养基中对照培养物的相应计数，在孵育18小时后测定生长抑制情况。在改良的、缺乏胸苷的莱文索尔肉汤中，与无药生长相比，所有测试分离株的菌落形成单位数量被TMP/SMZ（1.25/25μg/ml）降低了100倍或更多。TMP/SMZ的抑制作用明显大于单独使用TMP或SMZ。氨苄西林敏感株和氨苄西林耐药株对TMP/SMZ同样敏感。不可分型菌株的生长比b型菌株的生长受到的抑制更大。
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本文引用的文献
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Reversal of the antimicrobial activity of trimethoprim by thymidine in commercially prepared media.在商业制备的培养基中，胸腺嘧啶核苷可逆转甲氧苄啶的抗菌活性。
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