流感嗜血杆菌对甲氧苄啶-磺胺甲恶唑的体外敏感性
In vitro susceptibility of Haemophilus influenzae to trimethoprim-sulfamethoxazole.
作者信息
Kirven L A, Thornsberry C
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):869-70. doi: 10.1128/AAC.6.6.869.
Abstract
Thirty-four strains of Haemophilus influenzae (20 ampicillin sensitive and 14 ampicillin resistant), mostly type b isolates from cerebrospinal fluid or blood, were tested for susceptibility to a combination of trimethoprim-sulfamethoxazole (TMP-SMZ) in a ratio of 1 part TMP to 19 parts SMZ. All strains were very susceptible to the TMP-SMZ combination, with minimal inhibitory concentrations ranging from 0.007-0.14 to 0.06-1.18 mug of TMP-SMZ per ml. There was little difference in the susceptibility of the ampicillin-sensitive and ampicillin-resistant strains to TMP-SMZ.
摘要
对34株流感嗜血杆菌（20株对氨苄西林敏感，14株对氨苄西林耐药）进行了测试，这些菌株大多是从脑脊液或血液中分离出的b型菌株，检测其对甲氧苄啶-磺胺甲恶唑（TMP-SMZ）组合（甲氧苄啶与磺胺甲恶唑比例为1:19）的敏感性。所有菌株对TMP-SMZ组合都非常敏感，最低抑菌浓度范围为每毫升0.007 - 0.14至0.06 - 1.18微克TMP-SMZ。氨苄西林敏感菌株和氨苄西林耐药菌株对TMP-SMZ的敏感性差异不大。
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