Zbytniewski Z, Drewa G, Kanclerz A
Arch Geschwulstforsch. 1977;47(5):400-4.
The influence of two proteinase inhibitors -- Trasylol (Trascolan "Polfa") and PAMBA ("Germed") -- on experimental metastases of melanotic melanoma has been studied in golden hamsters. Animals were injected intravenously with tumour cells (5x10(5) or 10(6) in 0.2 ml of saline). They obtained protease inhibitor intraperitoneally one hour prior, or one hour after melanoma cells injection. One group of hamsters were also inoculated with tumour cells preincubated 10 min. in saline containing Trasylol or PAMBA. A diminished number of experimental metastases to the lungs in each group has been observed.
在金黄仓鼠中研究了两种蛋白酶抑制剂——抑肽酶（Trascolan“Polfa”）和对氨甲基苯甲酸（PAMBA，“Germed”）对黑素瘤实验性转移的影响。给动物静脉注射肿瘤细胞（在0.2毫升盐水中注射5×10⁵或10⁶个细胞）。在注射黑素瘤细胞前一小时或后一小时经腹腔给予蛋白酶抑制剂。还有一组仓鼠接种预先在含有抑肽酶或对氨甲基苯甲酸的盐水中孵育10分钟的肿瘤细胞。观察到每组中肺的实验性转移数量均减少。
